Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2480834..2481517 Replicon chromosome
Accession NZ_CP087993
Organism Xylella fastidiosa subsp. multiplex strain CFBP8416

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag XYFPCFBP8416_RS11135 Protein ID WP_004086858.1
Coordinates 2480834..2481262 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag XYFPCFBP8416_RS11140 Protein ID WP_004086856.1
Coordinates 2481263..2481517 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XYFPCFBP8416_RS11105 (XYFPCFBP8416_011035) 2477388..2478149 - 762 WP_004085598.1 Bax inhibitor-1/YccA family protein -
XYFPCFBP8416_RS11130 (XYFPCFBP8416_011060) 2479350..2480744 + 1395 WP_169710402.1 hypothetical protein -
XYFPCFBP8416_RS11135 (XYFPCFBP8416_011065) 2480834..2481262 - 429 WP_004086858.1 type II toxin-antitoxin system VapC family toxin Toxin
XYFPCFBP8416_RS11140 (XYFPCFBP8416_011070) 2481263..2481517 - 255 WP_004086856.1 hypothetical protein Antitoxin
XYFPCFBP8416_RS11145 (XYFPCFBP8416_011075) 2481642..2482184 + 543 WP_154436894.1 hypothetical protein -
XYFPCFBP8416_RS11150 (XYFPCFBP8416_011080) 2482505..2482878 - 374 Protein_2170 DUF596 domain-containing protein -
XYFPCFBP8416_RS11155 (XYFPCFBP8416_011085) 2482890..2483195 - 306 WP_228762248.1 DUF769 domain-containing protein -
XYFPCFBP8416_RS11160 (XYFPCFBP8416_011090) 2483394..2483786 - 393 WP_038211775.1 DUF596 domain-containing protein -
XYFPCFBP8416_RS11165 (XYFPCFBP8416_011095) 2483797..2484054 - 258 WP_021358680.1 hemagglutinin -
XYFPCFBP8416_RS11170 (XYFPCFBP8416_011100) 2484328..2484711 - 384 WP_004086848.1 DUF596 domain-containing protein -
XYFPCFBP8416_RS11175 (XYFPCFBP8416_011105) 2484716..2485753 - 1038 WP_169710105.1 DUF769 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15641.79 Da        Isoelectric Point: 5.1634

>T226527 WP_004086858.1 NZ_CP087993:c2481262-2480834 [Xylella fastidiosa subsp. multiplex]
MIVLDTNVVSEAMKPEPDAAVRTWLNEQMSVTLYLSSVTLSELLFGIAVLPTSKRKDMLARTLDGLLDLFNERVLPFDTD
AARHYAELAVKARNNGRGFPTPDGYIAAIAASRGYIVASRDTSAYESSGVQVINPWQYSKQT

Download         Length: 429 bp

>T226527 NZ_CP122507:1052028-1052363 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9601.95 Da        Isoelectric Point: 6.4732

>AT226527 WP_004086856.1 NZ_CP087993:c2481517-2481263 [Xylella fastidiosa subsp. multiplex]
MAMLTVRNLPDEVHRALRVRAATHGRSTEAEVREILTNIVKPDERVRIGDALAILGREIGLNNEDFTTFDKVRDKTQAEP
MRFE

Download         Length: 255 bp

>AT226527 NZ_CP122507:1051780-1052028 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGACTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References