Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1608750..1609272 Replicon chromosome
Accession NZ_CP087993
Organism Xylella fastidiosa subsp. multiplex strain CFBP8416

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag XYFPCFBP8416_RS07220 Protein ID WP_004085905.1
Coordinates 1608985..1609272 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A060HDF9
Locus tag XYFPCFBP8416_RS07215 Protein ID WP_004085758.1
Coordinates 1608750..1608992 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XYFPCFBP8416_RS07185 (XYFPCFBP8416_007135) 1604160..1604342 + 183 WP_027700467.1 hypothetical protein -
XYFPCFBP8416_RS07190 (XYFPCFBP8416_007140) 1604626..1605552 - 927 WP_004085766.1 Grx4 family monothiol glutaredoxin -
XYFPCFBP8416_RS07195 (XYFPCFBP8416_007145) 1605651..1606394 + 744 WP_225621865.1 polysaccharide deacetylase family protein -
XYFPCFBP8416_RS07200 (XYFPCFBP8416_007150) 1607038..1607229 - 192 WP_021358405.1 hypothetical protein -
XYFPCFBP8416_RS07205 (XYFPCFBP8416_007155) 1607647..1608066 - 420 WP_004085763.1 putative toxin-antitoxin system toxin component, PIN family -
XYFPCFBP8416_RS07210 (XYFPCFBP8416_007160) 1608066..1608305 - 240 WP_004085761.1 ribbon-helix-helix domain-containing protein -
XYFPCFBP8416_RS07215 (XYFPCFBP8416_007165) 1608750..1608992 + 243 WP_004085758.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
XYFPCFBP8416_RS07220 (XYFPCFBP8416_007170) 1608985..1609272 + 288 WP_004085905.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XYFPCFBP8416_RS07225 (XYFPCFBP8416_007175) 1609360..1609926 + 567 WP_004085755.1 recombinase family protein -
XYFPCFBP8416_RS07230 (XYFPCFBP8416_007180) 1609979..1611169 - 1191 WP_278279195.1 RNA-guided endonuclease TnpB family protein -
XYFPCFBP8416_RS07235 (XYFPCFBP8416_007185) 1611169..1611795 - 627 WP_038230952.1 IS607 family transposase -
XYFPCFBP8416_RS07240 (XYFPCFBP8416_007190) 1612025..1613299 - 1275 WP_012337985.1 pyridoxal phosphate-dependent aminotransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1607244..1628541 21297
- flank IS/Tn - - 1609360..1609926 566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-90)

Antitoxin

(1-78)


Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11159.64 Da        Isoelectric Point: 5.9570

>T226526 WP_004085905.1 NZ_CP087993:1608985-1609272 [Xylella fastidiosa subsp. multiplex]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLPDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL

Download         Length: 288 bp

>T226526 NZ_CP122507:914149-914556 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8774.77 Da        Isoelectric Point: 6.9881

>AT226526 WP_004085758.1 NZ_CP087993:1608750-1608992 [Xylella fastidiosa subsp. multiplex]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG

Download         Length: 243 bp

>AT226526 NZ_CP122507:913902-914168 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACAGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A060HDF9

References