Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/upstrm_HI1419-dnstrm_HI1420 |
| Location | 1335111..1335722 | Replicon | chromosome |
| Accession | NZ_CP087993 | ||
| Organism | Xylella fastidiosa subsp. multiplex strain CFBP8416 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A060HHU8 |
| Locus tag | XYFPCFBP8416_RS05940 | Protein ID | WP_024749166.1 |
| Coordinates | 1335111..1335410 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q879U0 |
| Locus tag | XYFPCFBP8416_RS05945 | Protein ID | WP_004085003.1 |
| Coordinates | 1335414..1335722 (+) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| XYFPCFBP8416_RS05900 (XYFPCFBP8416_005850) | 1330225..1331370 | - | 1146 | WP_169709940.1 | baseplate J/gp47 family protein | - |
| XYFPCFBP8416_RS05905 (XYFPCFBP8416_005855) | 1331473..1331769 | + | 297 | WP_004085590.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| XYFPCFBP8416_RS05910 (XYFPCFBP8416_005860) | 1331772..1332065 | + | 294 | WP_004085592.1 | putative addiction module antidote protein | - |
| XYFPCFBP8416_RS05915 (XYFPCFBP8416_005865) | 1332121..1332474 | - | 354 | WP_004084998.1 | hypothetical protein | - |
| XYFPCFBP8416_RS05920 (XYFPCFBP8416_005870) | 1332471..1333112 | - | 642 | WP_140189635.1 | Gp138 family membrane-puncturing spike protein | - |
| XYFPCFBP8416_RS05925 (XYFPCFBP8416_005875) | 1333109..1333939 | - | 831 | WP_004085594.1 | hypothetical protein | - |
| XYFPCFBP8416_RS05930 (XYFPCFBP8416_005880) | 1333936..1334253 | - | 318 | WP_012382585.1 | hypothetical protein | - |
| XYFPCFBP8416_RS05935 (XYFPCFBP8416_005885) | 1334253..1335023 | - | 771 | WP_272696003.1 | hypothetical protein | - |
| XYFPCFBP8416_RS05940 (XYFPCFBP8416_005890) | 1335111..1335410 | + | 300 | WP_024749166.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| XYFPCFBP8416_RS05945 (XYFPCFBP8416_005895) | 1335414..1335722 | + | 309 | WP_004085003.1 | putative addiction module antidote protein | Antitoxin |
| XYFPCFBP8416_RS05950 (XYFPCFBP8416_005900) | 1335796..1337568 | - | 1773 | WP_272696002.1 | hypothetical protein | - |
| XYFPCFBP8416_RS05955 (XYFPCFBP8416_005905) | 1337642..1337806 | - | 165 | WP_014607750.1 | hypothetical protein | - |
| XYFPCFBP8416_RS05960 (XYFPCFBP8416_005910) | 1337833..1338255 | - | 423 | WP_004085005.1 | putative phage tail assembly chaperone | - |
| XYFPCFBP8416_RS05965 (XYFPCFBP8416_005915) | 1338252..1338689 | - | 438 | WP_004085006.1 | DUF3277 family protein | - |
| XYFPCFBP8416_RS05970 (XYFPCFBP8416_005920) | 1338699..1340195 | - | 1497 | WP_004085007.1 | DUF3383 domain-containing protein | - |
| XYFPCFBP8416_RS05975 (XYFPCFBP8416_005925) | 1340196..1340600 | - | 405 | WP_012337895.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1328420..1370908 | 42488 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11364.14 Da Isoelectric Point: 10.3861
>T226525 WP_024749166.1 NZ_CP087993:1335111-1335410 [Xylella fastidiosa subsp. multiplex]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED
Download Length: 300 bp
>T226525 NZ_CP122507:751246-751542 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11060.61 Da Isoelectric Point: 4.6535
>AT226525 WP_004085003.1 NZ_CP087993:1335414-1335722 [Xylella fastidiosa subsp. multiplex]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH
Download Length: 309 bp
>AT226525 NZ_CP122507:751544-751939 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HHU8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HCD4 |