Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumAB/COG3657-dnstrm_HI1420 |
| Location | 1331473..1332065 | Replicon | chromosome |
| Accession | NZ_CP087993 | ||
| Organism | Xylella fastidiosa subsp. multiplex strain CFBP8416 | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | A0A060HCK8 |
| Locus tag | XYFPCFBP8416_RS05905 | Protein ID | WP_004085590.1 |
| Coordinates | 1331473..1331769 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | PumB | Uniprot ID | - |
| Locus tag | XYFPCFBP8416_RS05910 | Protein ID | WP_004085592.1 |
| Coordinates | 1331772..1332065 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| XYFPCFBP8416_RS05880 (XYFPCFBP8416_005830) | 1326643..1327611 | + | 969 | WP_004084992.1 | hypothetical protein | - |
| XYFPCFBP8416_RS05885 (XYFPCFBP8416_005835) | 1327870..1328316 | + | 447 | WP_004084994.1 | hypothetical protein | - |
| XYFPCFBP8416_RS05890 (XYFPCFBP8416_005840) | 1328420..1329664 | - | 1245 | WP_272696004.1 | phage tail protein | - |
| XYFPCFBP8416_RS05895 (XYFPCFBP8416_005845) | 1329668..1330228 | - | 561 | WP_004084996.1 | DUF2612 domain-containing protein | - |
| XYFPCFBP8416_RS05900 (XYFPCFBP8416_005850) | 1330225..1331370 | - | 1146 | WP_169709940.1 | baseplate J/gp47 family protein | - |
| XYFPCFBP8416_RS05905 (XYFPCFBP8416_005855) | 1331473..1331769 | + | 297 | WP_004085590.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| XYFPCFBP8416_RS05910 (XYFPCFBP8416_005860) | 1331772..1332065 | + | 294 | WP_004085592.1 | putative addiction module antidote protein | Antitoxin |
| XYFPCFBP8416_RS05915 (XYFPCFBP8416_005865) | 1332121..1332474 | - | 354 | WP_004084998.1 | hypothetical protein | - |
| XYFPCFBP8416_RS05920 (XYFPCFBP8416_005870) | 1332471..1333112 | - | 642 | WP_140189635.1 | Gp138 family membrane-puncturing spike protein | - |
| XYFPCFBP8416_RS05925 (XYFPCFBP8416_005875) | 1333109..1333939 | - | 831 | WP_004085594.1 | hypothetical protein | - |
| XYFPCFBP8416_RS05930 (XYFPCFBP8416_005880) | 1333936..1334253 | - | 318 | WP_012382585.1 | hypothetical protein | - |
| XYFPCFBP8416_RS05935 (XYFPCFBP8416_005885) | 1334253..1335023 | - | 771 | WP_272696003.1 | hypothetical protein | - |
| XYFPCFBP8416_RS05940 (XYFPCFBP8416_005890) | 1335111..1335410 | + | 300 | WP_024749166.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| XYFPCFBP8416_RS05945 (XYFPCFBP8416_005895) | 1335414..1335722 | + | 309 | WP_004085003.1 | putative addiction module antidote protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1328420..1370908 | 42488 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11169.70 Da Isoelectric Point: 10.0610
>T226524 WP_004085590.1 NZ_CP087993:1331473-1331769 [Xylella fastidiosa subsp. multiplex]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQRRGDTIYLLLCGGDKG
SQARDIKTALHLSEQWSE
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQRRGDTIYLLLCGGDKG
SQARDIKTALHLSEQWSE
Download Length: 297 bp
>T226524 NZ_CP122507:703231-703614 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10246.59 Da Isoelectric Point: 5.6232
>AT226524 WP_004085592.1 NZ_CP087993:1331772-1332065 [Xylella fastidiosa subsp. multiplex]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH
Download Length: 294 bp
>AT226524 NZ_CP122507:702773-703141 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|