Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 475054..475640 | Replicon | chromosome |
| Accession | NZ_CP087993 | ||
| Organism | Xylella fastidiosa subsp. multiplex strain CFBP8416 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q87BV5 |
| Locus tag | XYFPCFBP8416_RS02005 | Protein ID | WP_004089517.1 |
| Coordinates | 475386..475640 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | B2I6C9 |
| Locus tag | XYFPCFBP8416_RS02000 | Protein ID | WP_004085025.1 |
| Coordinates | 475054..475389 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| XYFPCFBP8416_RS01970 (XYFPCFBP8416_001960) | 471828..472361 | - | 534 | WP_050765486.1 | terminase small subunit | - |
| XYFPCFBP8416_RS01975 (XYFPCFBP8416_001965) | 472534..472758 | - | 225 | WP_012337656.1 | hypothetical protein | - |
| XYFPCFBP8416_RS01980 (XYFPCFBP8416_001970) | 472760..473221 | - | 462 | WP_169709972.1 | hypothetical protein | - |
| XYFPCFBP8416_RS01985 (XYFPCFBP8416_001975) | 473211..473540 | - | 330 | WP_004085022.1 | phage holin family protein | - |
| XYFPCFBP8416_RS01990 (XYFPCFBP8416_001980) | 473533..474033 | - | 501 | WP_128382956.1 | lysozyme | - |
| XYFPCFBP8416_RS01995 (XYFPCFBP8416_001985) | 474133..474864 | - | 732 | WP_169709925.1 | site-specific DNA-methyltransferase | - |
| XYFPCFBP8416_RS02000 (XYFPCFBP8416_001990) | 475054..475389 | - | 336 | WP_004085025.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| XYFPCFBP8416_RS02005 (XYFPCFBP8416_001995) | 475386..475640 | - | 255 | WP_004089517.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| XYFPCFBP8416_RS02010 (XYFPCFBP8416_002000) | 475693..476415 | - | 723 | WP_012337661.1 | hypothetical protein | - |
| XYFPCFBP8416_RS02015 (XYFPCFBP8416_002005) | 476358..476705 | - | 348 | WP_162010044.1 | hypothetical protein | - |
| XYFPCFBP8416_RS02020 (XYFPCFBP8416_002010) | 476893..478161 | + | 1269 | WP_249328055.1 | DNA polymerase | - |
| XYFPCFBP8416_RS02025 (XYFPCFBP8416_002015) | 478161..478436 | + | 276 | WP_201884958.1 | VRR-NUC domain-containing protein | - |
| XYFPCFBP8416_RS02030 (XYFPCFBP8416_002020) | 478438..478842 | - | 405 | WP_004085029.1 | hypothetical protein | - |
| XYFPCFBP8416_RS02035 (XYFPCFBP8416_002025) | 478927..480345 | + | 1419 | WP_169709926.1 | DEAD/DEAH box helicase | - |
| XYFPCFBP8416_RS02040 (XYFPCFBP8416_002030) | 480342..480506 | + | 165 | WP_004086189.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 435449..483184 | 47735 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9639.14 Da Isoelectric Point: 11.2766
>T226522 WP_004089517.1 NZ_CP087993:c475640-475386 [Xylella fastidiosa subsp. multiplex]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP
Download Length: 255 bp
>T226522 NZ_CP122507:c604938-604474 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12324.07 Da Isoelectric Point: 5.6556
>AT226522 WP_004085025.1 NZ_CP087993:c475389-475054 [Xylella fastidiosa subsp. multiplex]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT
Download Length: 336 bp
>AT226522 NZ_CP122507:c605273-604938 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q87BV5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HAK5 |