Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1481130..1481692 Replicon chromosome
Accession NZ_CP087977
Organism Janibacter limosus strain P1(28)-3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LP422_RS08705 Protein ID WP_257910405.1
Coordinates 1481130..1481459 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LP422_RS08710 Protein ID WP_272496134.1
Coordinates 1481456..1481692 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP422_RS08685 (LP422_08310) 1477265..1478491 + 1227 WP_257910401.1 FAD-dependent monooxygenase -
LP422_RS08690 (LP422_08315) 1478440..1479633 - 1194 WP_257910402.1 hypothetical protein -
LP422_RS08695 (LP422_08320) 1479762..1480724 - 963 WP_257910403.1 cation diffusion facilitator family transporter -
LP422_RS08700 (LP422_08325) 1480721..1481092 - 372 WP_257910404.1 metalloregulator ArsR/SmtB family transcription factor -
LP422_RS08705 (LP422_08330) 1481130..1481459 - 330 WP_257910405.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LP422_RS08710 (LP422_08335) 1481456..1481692 - 237 WP_272496134.1 antitoxin MazE5 Antitoxin
LP422_RS08715 (LP422_08340) 1481816..1482394 - 579 WP_257910406.1 DUF411 domain-containing protein -
LP422_RS08720 (LP422_08345) 1482542..1482970 - 429 WP_257910407.1 DUF305 domain-containing protein -
LP422_RS08725 (LP422_08350) 1483220..1483672 - 453 WP_257910408.1 hypothetical protein -
LP422_RS08730 (LP422_08355) 1483902..1485843 + 1942 Protein_1730 heavy metal translocating P-type ATPase -
LP422_RS08735 (LP422_08360) 1485748..1486248 - 501 WP_257910409.1 type II toxin-antitoxin system VapC family toxin -
LP422_RS08740 (LP422_08365) 1486251..1486520 - 270 WP_130629517.1 type II toxin-antitoxin system VapB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11746.69 Da        Isoelectric Point: 6.9037

>T226496 WP_257910405.1 NZ_CP087977:c1481459-1481130 [Janibacter limosus]
MTALPARGEVWWCEMAGIGRRPVVVLSRDSVIPRLRRSLVAPCTTTIRALASEVHLEPGEDPIPLRSAVNPDSVESVSVA
VLIERIGRLSDARMREVCAALAIAVDCSS

Download         Length: 330 bp

>T226496 NZ_CP122500:c89795-89490 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8358.28 Da        Isoelectric Point: 4.5700

>AT226496 WP_272496134.1 NZ_CP087977:c1481692-1481456 [Janibacter limosus]
MTRTRLSTTVDAELLASARGALPGLTDAKMLDEALSALVTRHRAAEIEAGYVAYDDHPLDEPDARGDLASFREAASRS

Download         Length: 237 bp

>AT226496 NZ_CP122500:c90015-89797 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References