Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 186903..187455 Replicon chromosome
Accession NZ_CP087977
Organism Janibacter limosus strain P1(28)-3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LP422_RS01165 Protein ID WP_257909093.1
Coordinates 186903..187217 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LP422_RS01170 Protein ID WP_257909095.1
Coordinates 187222..187455 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP422_RS01145 182864..183529 - 666 Protein_226 AMP-binding protein -
LP422_RS01150 (LP422_01110) 183617..184858 - 1242 WP_257909090.1 CoA transferase -
LP422_RS01155 (LP422_01115) 184907..185845 + 939 WP_257909091.1 MBL fold metallo-hydrolase -
LP422_RS01160 (LP422_01120) 185859..186897 - 1039 Protein_229 alcohol dehydrogenase catalytic domain-containing protein -
LP422_RS01165 (LP422_01125) 186903..187217 - 315 WP_257909093.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LP422_RS01170 (LP422_01130) 187222..187455 - 234 WP_257909095.1 ribbon-helix-helix domain-containing protein Antitoxin
LP422_RS01175 (LP422_01135) 188410..189846 + 1437 WP_257911118.1 IS1380 family transposase -
LP422_RS01180 (LP422_01140) 189869..191098 - 1230 WP_257909096.1 UvrD-helicase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 10977.71 Da        Isoelectric Point: 6.2786

>T226495 WP_257909093.1 NZ_CP087977:c187217-186903 [Janibacter limosus]
VREICPVRLDKTRPALVLTRETARGAMTKVTVAPITTTAKGLSSEVRVGRANGLDAECAVALDNVVTVPVELLGRTVGYL
SSTQEAELARAVVMAYDPDLPLTG

Download         Length: 315 bp

>T226495 NZ_CP122500:c32129-31980 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8358.38 Da        Isoelectric Point: 4.3304

>AT226495 WP_257909095.1 NZ_CP087977:c187455-187222 [Janibacter limosus]
MSTQIAVRLPDEMVEFLDRSVARGEAPSRAALVTSALEREMRRPAAEHDVAVLTERGTADDLDVVVEWTAAHVAVGD

Download         Length: 234 bp

>AT226495 NZ_CP122500:32173-32234 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References