Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3970606..3971193 Replicon chromosome
Accession NZ_CP087952
Organism Desulfosarcina sp. BuS5

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BuS5_RS19185 Protein ID WP_027354850.1
Coordinates 3970855..3971193 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BuS5_RS19180 Protein ID WP_027354849.1
Coordinates 3970606..3970854 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BuS5_RS19150 (BuS5_03840) 3966814..3967761 - 948 WP_198012316.1 integron integrase -
BuS5_RS19155 (BuS5_03841) 3968237..3968416 + 180 WP_027354845.1 hypothetical protein -
BuS5_RS19160 (BuS5_03842) 3968409..3968825 + 417 WP_027354846.1 type II toxin-antitoxin system VapC family toxin -
BuS5_RS19165 (BuS5_03843) 3969161..3969478 + 318 WP_027354847.1 DUF4258 domain-containing protein -
BuS5_RS19170 (BuS5_03844) 3969475..3969768 + 294 WP_051375122.1 YgiT-type zinc finger protein -
BuS5_RS19175 (BuS5_03845) 3969814..3970470 + 657 WP_027354848.1 DnaJ domain-containing protein -
BuS5_RS19180 (BuS5_03846) 3970606..3970854 + 249 WP_027354849.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BuS5_RS19185 (BuS5_03847) 3970855..3971193 + 339 WP_027354850.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BuS5_RS19190 (BuS5_03848) 3971273..3972046 + 774 WP_051375124.1 hypothetical protein -
BuS5_RS19195 3972390..3972536 - 147 WP_274427893.1 hypothetical protein -
BuS5_RS19200 (BuS5_03849) 3972944..3973762 + 819 WP_027355161.1 hypothetical protein -
BuS5_RS19205 (BuS5_03850) 3973764..3974300 + 537 WP_051375258.1 Panacea domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-107)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12691.63 Da        Isoelectric Point: 7.8587

>T226489 WP_027354850.1 NZ_CP087952:3970855-3971193 [Desulfosarcina sp. BuS5]
MSVYIPKQGDIIAITFDPQAGHEQKGRRPALVVSKDLFNRSTGLSIVCPITNTDRDFPFHVSIPEASKLTGFVMVEQVKS
VDFRARRVKRIERRNDELLSEVLSILDACIYE

Download         Length: 339 bp

>T226489 NZ_CP122499:2401161-2402483 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCTCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGCGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9140.65 Da        Isoelectric Point: 10.3840

>AT226489 WP_027354849.1 NZ_CP087952:3970606-3970854 [Desulfosarcina sp. BuS5]
MLAKIQKWGNSQGLRITKALLSDAQINVGDDVNIFVKDGALIVTPAQKVRKKYNLKDLVAKIPKGHQTKETDWGEPVGKE
VW

Download         Length: 249 bp

>AT226489 NZ_CP122499:2400895-2401161 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References