Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YefM
Location 3897731..3898305 Replicon chromosome
Accession NZ_CP087952
Organism Desulfosarcina sp. BuS5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BuS5_RS18840 Protein ID WP_255342816.1
Coordinates 3898018..3898305 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BuS5_RS18835 Protein ID WP_027354017.1
Coordinates 3897731..3898012 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BuS5_RS18790 (BuS5_03769) 3892929..3893216 - 288 WP_274427880.1 helix-turn-helix transcriptional regulator -
BuS5_RS18795 (BuS5_03770) 3893209..3893544 - 336 WP_274427881.1 type II toxin-antitoxin system RelE/ParE family toxin -
BuS5_RS18800 (BuS5_03771) 3893702..3893998 + 297 WP_274427882.1 transposase -
BuS5_RS18805 (BuS5_03772) 3894089..3894223 + 135 WP_274427883.1 hypothetical protein -
BuS5_RS18810 (BuS5_03773) 3894214..3894588 + 375 WP_274427884.1 hypothetical protein -
BuS5_RS18815 (BuS5_03775) 3895099..3895425 - 327 WP_035265484.1 DUF523 domain-containing protein -
BuS5_RS18820 (BuS5_03776) 3895422..3896123 - 702 WP_232223057.1 outer membrane protein assembly factor BamD -
BuS5_RS18825 (BuS5_03777) 3896110..3897036 - 927 WP_027354015.1 thioredoxin-disulfide reductase -
BuS5_RS18830 (BuS5_03778) 3897046..3897372 - 327 WP_027354016.1 thioredoxin -
BuS5_RS18835 (BuS5_03779) 3897731..3898012 + 282 WP_027354017.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BuS5_RS18840 3898018..3898305 + 288 WP_255342816.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BuS5_RS18845 (BuS5_03780) 3898398..3899981 - 1584 WP_027354018.1 peptide chain release factor 3 -
BuS5_RS18850 (BuS5_03781) 3900180..3901856 + 1677 WP_027354019.1 arginine--tRNA ligase -
BuS5_RS18855 (BuS5_03782) 3901866..3902495 + 630 WP_027354020.1 SPOR domain-containing protein -
BuS5_RS18860 (BuS5_03783) 3902610..3902897 + 288 WP_027354021.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10846.46 Da        Isoelectric Point: 4.7815

>T226488 WP_255342816.1 NZ_CP087952:3898018-3898305 [Desulfosarcina sp. BuS5]
IWSPLAVDRASEIADYIAQDKPSAAEKWIDTVFSKVAQLNSSPEIGRIVPEINDSQFKELIYGNYRILYRIEKEQISILT
IRHGCQILPINEIMA

Download         Length: 288 bp

>T226488 NZ_CP122499:2065830-2065933 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10517.34 Da        Isoelectric Point: 10.4928

>AT226488 WP_027354017.1 NZ_CP087952:3897731-3898012 [Desulfosarcina sp. BuS5]
MQKLKINQDIRSLSEVRNGMTNFIKQVHDTKRPVIIIQHGKGVAVLLAVNEFEAMQEKIELLSDIQTSLNQLGKGEGISH
KDAKEKVLKRVLK

Download         Length: 282 bp

>AT226488 NZ_CP122499:c2065971-2065700 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTAGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References