Detailed information of TA system TA226487

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 3596627..3597107
• Replicon: chromosome
• Accession: NZ_CP087952
• Organism: Desulfosarcina sp. BuS5

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: BuS5_RS17395
• Protein ID: WP_027353689.1
• Coordinates: 3596847..3597107 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: BuS5_RS17390
• Protein ID: WP_027353690.1
• Coordinates: 3596627..3596857 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BuS5_RS17380 (BuS5_03484)	3593877..3594851	+	975	WP_027353691.1	transposase	-
BuS5_RS17385 (BuS5_03485)	3594935..3596245	-	1311	WP_035265152.1	AAA family ATPase	-
BuS5_RS17390 (BuS5_03486)	3596627..3596857	-	231	WP_027353690.1	hypothetical protein	Antitoxin
BuS5_RS17395 (BuS5_03487)	3596847..3597107	-	261	WP_027353689.1	BrnT family toxin	Toxin
BuS5_RS17400 (BuS5_03488)	3597401..3598663	-	1263	WP_157487365.1	AAA family ATPase	-
BuS5_RS17405 (BuS5_03489)	3598921..3601749	-	2829	WP_027353687.1	excinuclease ABC subunit UvrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10024.30 Da
• Isoelectric Point: 4.9001

>T226487 WP_027353689.1 NZ_CP087952:c3597107-3596847 [Desulfosarcina sp. BuS5]
MSFEFDQKKSDTNKIKHGIDFVEAQELLNDVDLLEIPAKTIDESRFLVIGKIGEKHWAGITTYRNNNIRIISARRARDEE
IELYES

Nucleotide

• Length: 261 bp

>T226487 NZ_CP122499:c1903345-1902968 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9003.53 Da
• Isoelectric Point: 10.7058

>AT226487 WP_027353690.1 NZ_CP087952:c3596857-3596627 [Desulfosarcina sp. BuS5]
MKAEELDKKFDEGKSILKNFDFSKARRLNQEQKRVNVDFPIWMIQSLDKEAKRLGVPRQSIIKIWLAERLNKTATI

Nucleotide

• Length: 231 bp

>AT226487 NZ_CP122499:c1903803-1903435 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCACCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA