Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 2656518..2657153 Replicon chromosome
Accession NZ_CP087952
Organism Desulfosarcina sp. BuS5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BuS5_RS13055 Protein ID WP_035265350.1
Coordinates 2656752..2657153 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BuS5_RS13050 Protein ID WP_027353881.1
Coordinates 2656518..2656748 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BuS5_RS13035 (BuS5_02620) 2651801..2653888 + 2088 WP_027353884.1 PEP-CTERM system histidine kinase PrsK -
BuS5_RS13040 (BuS5_02621) 2654036..2654575 - 540 WP_027353883.1 PEP-CTERM sorting domain-containing protein -
BuS5_RS13045 (BuS5_02623) 2655042..2656244 - 1203 WP_027353882.1 ATP-binding protein -
BuS5_RS13050 (BuS5_02624) 2656518..2656748 + 231 WP_027353881.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BuS5_RS13055 (BuS5_02625) 2656752..2657153 + 402 WP_035265350.1 type II toxin-antitoxin system VapC family toxin Toxin
BuS5_RS13060 (BuS5_02626) 2657271..2657474 - 204 WP_027353879.1 type II toxin-antitoxin system VapB family antitoxin -
BuS5_RS13065 (BuS5_02627) 2657833..2659209 - 1377 WP_035265358.1 PEP-CTERM-box response regulator transcription factor -
BuS5_RS13070 (BuS5_02628) 2659215..2660270 - 1056 WP_051374763.1 histone deacetylase -
BuS5_RS13075 (BuS5_02629) 2660425..2661669 - 1245 WP_232223045.1 nucleoside transporter C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(8-131)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-43)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15753.31 Da        Isoelectric Point: 6.3721

>T226485 WP_035265350.1 NZ_CP087952:2656752-2657153 [Desulfosarcina sp. BuS5]
MHNSTDYLIDTHCWLWWHIEPDRLAGQTLELIKNAETVIFFSVVSAWEIIIKYNLKKLRLPLSPSLYITKRLEISYMEVM
PVHFAHVLQVEKLPDYHKDPFDRLLIAQAVTENLTVITCDHQYRQYDVKIIDG

Download         Length: 402 bp

>T226485 NZ_CP122499:1890037-1890288 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8401.72 Da        Isoelectric Point: 10.3158

>AT226485 WP_027353881.1 NZ_CP087952:2656518-2656748 [Desulfosarcina sp. BuS5]
MLTVNTHEAKTQLSRLLVRVSHGEEIVIAKSGKPVARLVPAKQNFAKRKPGIDKGKAWVADDFDAALPETLQSFFE

Download         Length: 231 bp

>AT226485 NZ_CP122499:1890285-1890539 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References