Detailed information of TA system TA226484

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 2115413..2115663
• Replicon: chromosome
• Accession: NZ_CP087952
• Organism: Desulfosarcina sp. BuS5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BuS5_RS10405
• Protein ID: WP_274427646.1
• Coordinates: 2115413..2115532 (-)
• Length: 40 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: BuS5_RS10410
• Protein ID: WP_232223021.1
• Coordinates: 2115529..2115663 (-)
• Length: 45 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BuS5_RS10375 (BuS5_02103)	2111306..2113144	+	1839	WP_051375227.1	DUF3141 domain-containing protein	-
BuS5_RS10380 (BuS5_02104)	2113591..2114070	-	480	WP_274427645.1	hypothetical protein	-
BuS5_RS10385	2114180..2114410	+	231	WP_027353235.1	hypothetical protein	-
BuS5_RS10390 (BuS5_02105)	2114466..2114762	+	297	WP_027353236.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BuS5_RS10395 (BuS5_02106)	2114771..2115082	+	312	WP_035264614.1	HigA family addiction module antitoxin	-
BuS5_RS10400	2115278..2115337	-	60	Protein_2052	hypothetical protein	-
BuS5_RS10405	2115413..2115532	-	120	WP_274427646.1	type II toxin-antitoxin system YoeB family toxin	Toxin
BuS5_RS10410	2115529..2115663	-	135	WP_232223021.1	hypothetical protein	Antitoxin
BuS5_RS10415 (BuS5_02110)	2116158..2117480	-	1323	WP_084445675.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-109)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 40 a.a.
• Molecular weight: 4764.20 Da
• Isoelectric Point: 7.1975

>T226484 WP_274427646.1 NZ_CP087952:c2115532-2115413 [Desulfosarcina sp. BuS5]
VKLIFSDHAWDDYLFWQNTDKKSSSSYQYPHQRNETKSI

Nucleotide

• Length: 120 bp

>T226484 NZ_CP122499:1047008-1047343 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 45 a.a.
• Molecular weight: 5082.71 Da
• Isoelectric Point: 4.2881

>AT226484 WP_232223021.1 NZ_CP087952:c2115663-2115529 [Desulfosarcina sp. BuS5]
MSLEDYEALEETAYLLRSPKNTRRLIESIAQLENGKGTEKELLE

Nucleotide

• Length: 135 bp

>AT226484 NZ_CP122499:1046760-1047008 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGACTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA