Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-graA/PIN-HigA
Location 1418811..1419460 Replicon chromosome
Accession NZ_CP087952
Organism Desulfosarcina sp. BuS5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BuS5_RS07065 Protein ID WP_027353187.1
Coordinates 1419104..1419460 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag BuS5_RS07060 Protein ID WP_027353186.1
Coordinates 1418811..1419110 (-) Length 100 a.a.

Genomic Context

BuS5_RS07080BuS5_RS07035BuS5_RS07040BuS5_RS07045BuS5_RS07050BuS5_RS07055BuS5_RS07060BuS5_RS07065BuS5_RS07070BuS5_RS07075BuS5_RS07085BuS5_RS07090
Location: 1420980..1422353 (1374 bp)
Type: Others
Protein ID: WP_036019348.1
Location: 1415391..1416353 (963 bp)
Type: Others
Protein ID: WP_027353183.1
Location: 1416464..1416892 (429 bp)
Type: Others
Protein ID: WP_051374606.1
Location: 1416889..1417167 (279 bp)
Type: Others
Protein ID: WP_027353184.1
Location: 1417320..1417433 (114 bp)
Type: Others
Protein ID: WP_157487324.1
Location: 1417423..1418733 (1311 bp)
Type: Others
Protein ID: WP_027353185.1
Location: 1418811..1419110 (300 bp)
Type: Antitoxin
Protein ID: WP_027353186.1
Location: 1419104..1419460 (357 bp)
Type: Toxin
Protein ID: WP_027353187.1
Location: 1419492..1419719 (228 bp)
Type: Others
Protein ID: WP_027353188.1
Location: 1419904..1420224 (321 bp)
Type: Others
Protein ID: WP_027353189.1
Location: 1422606..1422980 (375 bp)
Type: Others
Protein ID: WP_027354376.1
Location: 1423089..1423367 (279 bp)
Type: Others
Protein ID: WP_157487425.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BuS5_RS07035 (BuS5_01436)1415391..1416353-963WP_027353183.1hypothetical protein-
BuS5_RS07040 (BuS5_01437)1416464..1416892-429WP_051374606.1type II toxin-antitoxin system VapC family toxin-
BuS5_RS07045 (BuS5_01438)1416889..1417167-279WP_027353184.1type II toxin-antitoxin system prevent-host-death family antitoxin-
BuS5_RS07050 (BuS5_01439)1417320..1417433-114WP_157487324.1GxxExxY protein-
BuS5_RS07055 (BuS5_01440)1417423..1418733-1311WP_027353185.1tetratricopeptide repeat protein-
BuS5_RS07060 (BuS5_01441)1418811..1419110-300WP_027353186.1HigA family addiction module antitoxinAntitoxin
BuS5_RS07065 (BuS5_01442)1419104..1419460-357WP_027353187.1type II toxin-antitoxin system VapC family toxinToxin
BuS5_RS07070 (BuS5_01443)1419492..1419719-228WP_027353188.1type II toxin-antitoxin system prevent-host-death family antitoxin-
BuS5_RS07075 (BuS5_01444)1419904..1420224-321WP_027353189.1hypothetical protein-
BuS5_RS07080 (BuS5_01445)1420980..1422353+1374WP_036019348.1group II intron reverse transcriptase/maturase-
BuS5_RS07085 (BuS5_01447)1422606..1422980-375WP_027354376.1hypothetical protein-
BuS5_RS07090 (BuS5_01448)1423089..1423367-279WP_157487425.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(2-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13956.36 Da        Isoelectric Point: 5.2244

>T226481 WP_027353187.1 NZ_CP087952:c1419460-1419104 [Desulfosarcina sp. BuS5]
MWFIGGNKKLSNEARKFIESFENELVMSVASLWETAIKISIGKLEFYKCFEVLISEKIEENEIDILQINLKHFSEMMKLP
FHHRDPFDRLIIAQGISERIPIITCDYAFKIYPVDIIW

Download         Length: 357 bp

>T226481 NZ_CP122499:733641-733937 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGATTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10920.55 Da        Isoelectric Point: 7.8307

>AT226481 WP_027353186.1 NZ_CP087952:c1419110-1418811 [Desulfosarcina sp. BuS5]
MVNKISPIHPGEVLFEDFLKPMNISQNQLAGDLAVSTRRINEIVNCKRSITADTALRLAACFGNSPSFWPGLQMEYDLDA
AEDALSSKIKKVVRRQASA

Download         Length: 300 bp

>AT226481 NZ_CP122499:733939-734334 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References