Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 38405..38933 Replicon plasmid p3ABAYE
Accession NC_010404
Organism Acinetobacter baumannii AYE

Toxin (Protein)


Gene name relE Uniprot ID B0V430
Locus tag ABAYE_RS00290 Protein ID WP_000221360.1
Coordinates 38640..38933 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B0V429
Locus tag ABAYE_RS00285 Protein ID WP_000246757.1
Coordinates 38405..38650 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABAYE_RS00260 33807..34805 + 999 WP_000649020.1 zinc-binding alcohol dehydrogenase family protein -
ABAYE_RS00265 34826..35110 + 285 WP_000155817.1 antibiotic biosynthesis monooxygenase -
ABAYE_RS20115 35245..35466 + 222 Protein_35 IS3 family transposase -
ABAYE_RS00270 35876..36394 + 519 WP_000447196.1 sel1 repeat family protein -
ABAYE_RS00275 36526..37038 + 513 WP_001089570.1 SMI1/KNR4 family protein -
ABAYE_RS00280 37246..38148 + 903 WP_000466974.1 hypothetical protein -
ABAYE_RS00285 38405..38650 + 246 WP_000246757.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ABAYE_RS00290 38640..38933 + 294 WP_000221360.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABAYE_RS19510 39120..39236 + 117 Protein_41 transposase -
ABAYE_RS00295 40251..40559 + 309 WP_000269910.1 type II toxin-antitoxin system RelE/ParE family toxin -
ABAYE_RS00300 40600..40902 + 303 WP_001140619.1 XRE family transcriptional regulator -
ABAYE_RS00305 40895..41104 + 210 WP_000069470.1 hypothetical protein -
ABAYE_RS00310 41214..41441 - 228 WP_000555567.1 hypothetical protein -
ABAYE_RS00315 42207..42510 - 304 Protein_46 helix-turn-helix transcriptional regulator -
ABAYE_RS00320 42503..42859 - 357 WP_000269908.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94413 94413


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11317.49 Da        Isoelectric Point: 10.4753

>T22648 WP_000221360.1 NC_010404:38640-38933 [Acinetobacter baumannii AYE]
MTYKLLRNKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLRGDLTGCYKIKLLKTGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T22648 NC_010404:38640-38933 [Acinetobacter baumannii AYE]
ATGACTTATAAGCTTTTACGTAATAAGGACTTCACAGCTGAATGGGAAAAGCTTCCTAGTGCTATAAGAGATCAATTTAA
GAAGAAACTCGCCAAGGTCATAGAGCAGCCACATATTCCCAAGAATATGCTTAGAGGTGATCTCACGGGATGTTATAAAA
TTAAATTACTAAAGACTGGAGTTCGACTGGTCTATCAAGTCAAAGATGATCAGGTAGTTATCTTGCTCATCACCGTTGGG
AAACGAGCTGACAGCATAGTTTATGACGAAGCAAAAAAACGCATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9264.63 Da        Isoelectric Point: 4.2821

>AT22648 WP_000246757.1 NC_010404:38405-38650 [Acinetobacter baumannii AYE]
MATVNFRVDEALKEKSYSVLREQGIAPTEFFTNVLEYIAATGKLPVQKALLSEEDTELLAIVRKRMNDPKEMFEEITLDD
L

Download         Length: 246 bp

>AT22648 NC_010404:38405-38650 [Acinetobacter baumannii AYE]
ATGGCTACTGTTAACTTCAGGGTTGATGAAGCCCTTAAAGAAAAATCTTATTCAGTTCTTAGAGAACAAGGTATTGCACC
TACTGAGTTTTTTACAAATGTCCTTGAATACATTGCAGCGACTGGGAAACTCCCTGTACAAAAAGCTTTACTCTCAGAAG
AGGATACCGAGCTATTAGCGATTGTTCGTAAACGTATGAATGATCCTAAAGAAATGTTCGAGGAAATTACTTTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829RR87

Antitoxin

Source ID Structure
AlphaFold DB A0A009MZ79

References