Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 967704..968281 Replicon chromosome
Accession NZ_CP087952
Organism Desulfosarcina sp. BuS5

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BuS5_RS04745 Protein ID WP_027354938.1
Coordinates 967943..968281 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BuS5_RS04740 Protein ID WP_027354939.1
Coordinates 967704..967943 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BuS5_RS04715 963589..963711 + 123 WP_274428048.1 hypothetical protein -
BuS5_RS04720 (BuS5_00973) 964070..964408 + 339 WP_027354943.1 type II toxin-antitoxin system RelE/ParE family toxin -
BuS5_RS04725 (BuS5_00974) 964401..965510 + 1110 WP_035266443.1 HigA family addiction module antitoxin -
BuS5_RS04730 (BuS5_00975) 965930..966994 + 1065 WP_027354941.1 hypothetical protein -
BuS5_RS04735 (BuS5_00976) 966991..967278 + 288 WP_035266442.1 hypothetical protein -
BuS5_RS04740 (BuS5_00978) 967704..967943 + 240 WP_027354939.1 MazF family transcriptional regulator Antitoxin
BuS5_RS04745 (BuS5_00979) 967943..968281 + 339 WP_027354938.1 endoribonuclease MazF Toxin
BuS5_RS04750 (BuS5_00980) 969345..969650 + 306 WP_027354937.1 nucleotidyltransferase domain-containing protein -
BuS5_RS04755 (BuS5_00981) 969643..970068 + 426 WP_051375151.1 DUF86 domain-containing protein -
BuS5_RS04760 (BuS5_00982) 970136..971290 + 1155 WP_036019371.1 IS4 family transposase -
BuS5_RS04765 (BuS5_00983) 971413..972399 + 987 WP_274428049.1 IS1 family transposase -
BuS5_RS04770 (BuS5_00984) 972349..973047 - 699 WP_274428050.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-106)

Antitoxin

Antitoxin PemI-like

(1-79)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12683.71 Da        Isoelectric Point: 7.2426

>T226478 WP_027354938.1 NZ_CP087952:967943-968281 [Desulfosarcina sp. BuS5]
MYVPDRCHVVWLQFNPQTGHEQAGHRPALVISPATYNGKTGLALFCPITNQIKGYPFEVKIKDNPTISGVVLADQVKNLD
WRVRGVKFVTMVDETLLEEVLSKFEALIRMNE

Download         Length: 339 bp

>T226478 NZ_CP122499:198625-198732 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTTGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8975.31 Da        Isoelectric Point: 5.8426

>AT226478 WP_027354939.1 NZ_CP087952:967704-967943 [Desulfosarcina sp. BuS5]
MKAKTVKIGNNLAFMIPQSIAAKCRLEENDSFDFSLRKDEIVIRSINKRYNLSDLLAGITQENLHEEVGRDEPVGKEIL

Download         Length: 240 bp

>AT226478 NZ_CP122499:c198577-198511 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References