Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 716664..718315 Replicon chromosome
Accession NZ_CP087952
Organism Desulfosarcina sp. BuS5

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag BuS5_RS03385 Protein ID WP_027354123.1
Coordinates 716664..717968 (-) Length 435 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag BuS5_RS03390 Protein ID WP_027354124.1
Coordinates 717965..718315 (-) Length 117 a.a.

Genomic Context

BuS5_RS03355BuS5_RS03360BuS5_RS03365BuS5_RS03370BuS5_RS03375BuS5_RS03395BuS5_RS03400BuS5_RS03380BuS5_RS03385BuS5_RS03390BuS5_RS03405BuS5_RS03410BuS5_RS03415
Location: 712542..713417 (876 bp)
Type: Others
Protein ID: WP_027354118.1
Location: 713552..714358 (807 bp)
Type: Others
Protein ID: WP_027354119.1
Location: 714424..714834 (411 bp)
Type: Others
Protein ID: WP_027354120.1
Location: 714850..715527 (678 bp)
Type: Others
Protein ID: WP_027354121.1
Location: 715585..715920 (336 bp)
Type: Others
Protein ID: WP_051374822.1
Location: 718972..719553 (582 bp)
Type: Others
Protein ID: WP_084446021.1
Location: 719550..720128 (579 bp)
Type: Others
Protein ID: WP_027354125.1
Location: 715861..716709 (849 bp)
Type: Others
Protein ID: WP_157487404.1
Location: 716664..717968 (1305 bp)
Type: Toxin
Protein ID: WP_027354123.1
Location: 717965..718315 (351 bp)
Type: Antitoxin
Protein ID: WP_027354124.1
Location: 720207..721229 (1023 bp)
Type: Others
Protein ID: WP_027354126.1
Location: 721361..722539 (1179 bp)
Type: Others
Protein ID: WP_027354127.1
Location: 722616..722753 (138 bp)
Type: Others
Protein ID: WP_232223068.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BuS5_RS03355 (BuS5_00683)712542..713417+876WP_027354118.1DUF350 domain-containing protein-
BuS5_RS03360 (BuS5_00684)713552..714358+807WP_027354119.1hypothetical protein-
BuS5_RS03365 (BuS5_00685)714424..714834+411WP_027354120.1hypothetical protein-
BuS5_RS03370 (BuS5_00686)714850..715527+678WP_027354121.1PspA/IM30 family protein-
BuS5_RS03375 (BuS5_00687)715585..715920+336WP_051374822.1S-adenosylmethionine decarboxylase-
BuS5_RS03380 (BuS5_00688)715861..716709-849WP_157487404.1TIGR02757 family protein-
BuS5_RS03385 (BuS5_00689)716664..717968-1305WP_027354123.1type II toxin-antitoxin system HipA family toxinToxin
BuS5_RS03390 (BuS5_00690)717965..718315-351WP_027354124.1helix-turn-helix transcriptional regulatorAntitoxin
BuS5_RS03395 (BuS5_00691)718972..719553+582WP_084446021.1DUF2092 domain-containing protein-
BuS5_RS03400 (BuS5_00692)719550..720128+579WP_027354125.1hypothetical protein-
BuS5_RS03405 (BuS5_00693)720207..721229-1023WP_027354126.1hypothetical protein-
BuS5_RS03410 (BuS5_00694)721361..722539-1179WP_027354127.1FprA family A-type flavoprotein-
BuS5_RS03415 (BuS5_00695)722616..722753-138WP_232223068.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(170-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-68)


Sequences

Toxin        


Download         Length: 435 a.a.        Molecular weight: 49119.43 Da        Isoelectric Point: 9.2873

>T226473 WP_027354123.1 NZ_CP087952:c717968-716664 [Desulfosarcina sp. BuS5]
MSQVAEVKLWERTIGALSLEEGKEVADFEYDPAFAGSGIEIAPLTMPLANRVYSFPELSRMTFRGLPGLIADSLPDRFGH
ALIDVWLATRGQPPESFNAVERLCYIGRRGMGALEFEPAIGPKARKSTRVQVDKLVELASEILTHRKNLKVSFAGKKKER
ALREILKVGTSAGGARAKAVIAWNPLTNEVRSGQIPAGEGFEYWLLKFDGVKGNKDKEIEDPKGYGVIEYTYYKMATDAG
ITMSECRLFEENNRRHFMTRRFDRLDNGEKLHMQSLCALAHYDFNMAGAYAYEQALLVIRQLGLPMSAIEEQFRRMAFNI
ISRNQDDHVKNIAFLMDKSGKWSLSPAFDITYSFNPSGKWTVSHQMTMNGKRDNFRMEDFKACAMVASMKRGRAETIVNE
VLKTVSRWRDYADEAGVSPLWRDGIQQTLRLKIL

Download         Length: 1305 bp

>T226473 NZ_CP122496:c4010779-4010429 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCAGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGAAATAA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13221.33 Da        Isoelectric Point: 10.9210

>AT226473 WP_027354124.1 NZ_CP087952:c718315-717965 [Desulfosarcina sp. BuS5]
MFNFKTMTDDAVLEELGRRLERRRIDLKLTQAKLAEQAGVSKRTLERMEAGAVTQTRNLIRILRMLDLLQGFEQLIPVTG
PSPMDLLKFKGKERKRASSSSAVKQSPKTWSWGDDS

Download         Length: 351 bp

>AT226473 NZ_CP122496:c4011024-4010773 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCTACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References