22647

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 4352..4940 Replicon plasmid p2ABAYE
Accession NC_010402
Organism Acinetobacter baumannii AYE

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag ABAYE_RS00055 Protein ID WP_000438826.1
Coordinates 4352..4639 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag ABAYE_RS00060 Protein ID WP_001983304.1
Coordinates 4626..4940 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABAYE_RS00040 662..1612 + 951 WP_001205343.1 replication initiation protein RepM -
ABAYE_RS00045 1605..2180 + 576 WP_001096616.1 helix-turn-helix domain-containing protein -
ABAYE_RS20490 2200..2343 + 144 WP_001125246.1 hypothetical protein -
ABAYE_RS00050 2822..3904 - 1083 WP_006582650.1 zinc-dependent alcohol dehydrogenase family protein -
ABAYE_RS00055 4352..4639 + 288 WP_000438826.1 BrnT family toxin Toxin
ABAYE_RS00060 4626..4940 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
ABAYE_RS00065 5068..7479 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
ABAYE_RS00070 7784..8245 + 462 WP_000761346.1 DIP1984 family protein -
ABAYE_RS20495 8568..8741 - 174 WP_001282484.1 hypothetical protein -
ABAYE_RS00075 8741..9112 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..9661 9661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T22647 WP_000438826.1 NC_010402:4352-4639 [Acinetobacter baumannii AYE]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T22647 NC_010402:4352-4639 [Acinetobacter baumannii AYE]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT22647 WP_001983304.1 NC_010402:4626-4940 [Acinetobacter baumannii AYE]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT22647 NC_010402:4626-4940 [Acinetobacter baumannii AYE]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References