Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4038779..4039388 Replicon chromosome
Accession NZ_CP087880
Organism Pseudocitrobacter corydidari isolate G163CM

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G163CM_RS18740 Protein ID WP_231825934.1
Coordinates 4038779..4038964 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G163CM_RS18745 Protein ID WP_015962515.1
Coordinates 4038981..4039388 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G163CM_RS18720 (4035262) 4035262..4035585 + 324 WP_015962510.1 DUF3302 domain-containing protein -
G163CM_RS18725 (4035591) 4035591..4036727 + 1137 WP_231825932.1 HlyD family secretion protein -
G163CM_RS18730 (4036724) 4036724..4037698 - 975 WP_015962512.1 LysR family transcriptional regulator -
G163CM_RS18735 (4037822) 4037822..4038562 + 741 WP_231825933.1 MipA/OmpV family protein -
G163CM_RS18740 (4038779) 4038779..4038964 + 186 WP_231825934.1 type II toxin-antitoxin system HicA family toxin Toxin
G163CM_RS18745 (4038981) 4038981..4039388 + 408 WP_015962515.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G163CM_RS18750 (4039385) 4039385..4039696 - 312 WP_015962516.1 hypothetical protein -
G163CM_RS18755 (4039797) 4039797..4040492 - 696 WP_231825935.1 L-ribulose-5-phosphate 4-epimerase -
G163CM_RS18760 (4040486) 4040486..4041346 - 861 WP_231825936.1 L-ribulose-5-phosphate 3-epimerase -
G163CM_RS18765 (4041346) 4041346..4042002 - 657 WP_231825937.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
G163CM_RS18770 (4041999) 4041999..4043504 - 1506 WP_231825938.1 FGGY-family carbohydrate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6709.85 Da        Isoelectric Point: 12.0346

>T226456 WP_231825934.1 NZ_CP087880:4038779-4038964 [Pseudocitrobacter corydidari]
VKSAEVIAILKQHGSVHVRTRGSHQQFHHPSRAGLVTVPHPRKDIKPGTLAQICRQAGIKM

Download         Length: 186 bp

>T226456 NZ_CP122493:92113-92400 [Escherichia coli]
ATGACTTATACAGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14991.88 Da        Isoelectric Point: 4.6864

>AT226456 WP_015962515.1 NZ_CP087880:4038981-4039388 [Pseudocitrobacter corydidari]
MFYPAYIHTDPDGSSSGFFPDVPGCYFAGDTLDDTFQDARGALVAHFEALCELNKELPLPGSVETHLACDPQNYAGGQWL
LVDINMNQFEGKAERINITMPKRLLQKIDAFVRHNPDYANRSAFLAEAARRVLPG

Download         Length: 408 bp

>AT226456 NZ_CP122493:91865-92116 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCGGAACTCTATGAAAGGATGC
TTGATGCGCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References