Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 3548743..3549415 Replicon chromosome
Accession NZ_CP087880
Organism Pseudocitrobacter corydidari isolate G163CM

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag G163CM_RS16515 Protein ID WP_231825668.1
Coordinates 3549068..3549415 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag G163CM_RS16510 Protein ID WP_231825667.1
Coordinates 3548743..3549066 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G163CM_RS16480 (3544019) 3544019..3544426 + 408 WP_015966355.1 mannose/fructose/sorbose PTS transporter subunit IIA -
G163CM_RS16485 (3544426) 3544426..3544920 + 495 WP_231825664.1 PTS system mannose/fructose/N-acetylgalactosamine-transporter subunit IIB -
G163CM_RS16490 (3544985) 3544985..3545782 + 798 WP_015966357.1 PTS mannose/fructose/sorbose transporter subunit IIC -
G163CM_RS16495 (3545794) 3545794..3546618 + 825 WP_015966358.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
G163CM_RS16500 (3546670) 3546670..3547899 + 1230 WP_231825665.1 L-sorbose 1-phosphate reductase -
G163CM_RS16505 (3547892) 3547892..3548704 + 813 WP_231825666.1 shikimate 5-dehydrogenase -
G163CM_RS16510 (3548743) 3548743..3549066 - 324 WP_231825667.1 helix-turn-helix transcriptional regulator Antitoxin
G163CM_RS16515 (3549068) 3549068..3549415 - 348 WP_231825668.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G163CM_RS16520 (3549630) 3549630..3550319 + 690 WP_231825669.1 dipeptidase PepE -
G163CM_RS16525 (3550411) 3550411..3552042 - 1632 WP_015966362.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12978.95 Da        Isoelectric Point: 9.9183

>T226452 WP_231825668.1 NZ_CP087880:c3549415-3549068 [Pseudocitrobacter corydidari]
MSKPLYWVGQSRKDLQAMPEHIQDVFGYALWLAQQGQKHPQAKPLKGFGCAGILEVVEDFHGNTWRAVYTVTLRDAVYVL
HVFQKKSSSGISTPKLEIDLIYQRLKAAQRHAQGG

Download         Length: 348 bp

>T226452 NZ_CP122492:c4711048-4710737 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11647.59 Da        Isoelectric Point: 7.8895

>AT226452 WP_231825667.1 NZ_CP087880:c3549066-3548743 [Pseudocitrobacter corydidari]
MSQNVDVSCGNVYEDLGIHNAEQMQLKAHLALAISEILQRKGLTQQQAAHILGMTQPKLSNLLRGQFRGISEAKMLECLV
KLGRDVEIVVGKQSATGGSLKVIFAEM

Download         Length: 324 bp

>AT226452 NZ_CP122492:c4710736-4710446 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References