Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1771035..1771703 Replicon chromosome
Accession NC_010380
Organism Streptococcus pneumoniae Hungary19A-6

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag SPH_RS09285 Protein ID WP_001132285.1
Coordinates 1771524..1771703 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B1I7P9
Locus tag SPH_RS09280 Protein ID WP_000961813.1
Coordinates 1771035..1771487 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPH_RS09255 1766925..1767668 - 744 WP_001188180.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
SPH_RS09260 1767670..1768620 - 951 WP_000451169.1 50S ribosomal protein L11 methyltransferase -
SPH_RS09265 1768758..1769186 - 429 WP_000401989.1 NUDIX hydrolase -
SPH_RS09270 1769188..1770255 - 1068 WP_000719721.1 M50 family metallopeptidase -
SPH_RS09275 1770274..1770744 - 471 WP_000257097.1 DUF3013 family protein -
SPH_RS09280 1771035..1771487 - 453 WP_000961813.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPH_RS09285 1771524..1771703 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
SPH_RS09290 1771840..1772019 - 180 WP_001048906.1 hypothetical protein -
SPH_RS09295 1772184..1772399 - 216 WP_075329187.1 hypothetical protein -
SPH_RS09300 1772697..1773968 + 1272 WP_001113222.1 replication-associated recombination protein A -
SPH_RS09310 1774513..1775832 - 1320 WP_000608879.1 glycoside hydrolase family 32 protein -
SPH_RS09315 1775842..1776687 - 846 WP_000819520.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T22645 WP_001132285.1 NC_010380:c1771703-1771524 [Streptococcus pneumoniae Hungary19A-6]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T22645 NC_010380:c1771703-1771524 [Streptococcus pneumoniae Hungary19A-6]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16689.48 Da        Isoelectric Point: 3.7220

>AT22645 WP_000961813.1 NC_010380:c1771487-1771035 [Streptococcus pneumoniae Hungary19A-6]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISETLAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT22645 NC_010380:c1771487-1771035 [Streptococcus pneumoniae Hungary19A-6]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGACTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATAAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
AlphaFold DB B1I7P9

References