Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1325739..1327318 Replicon chromosome
Accession NZ_CP087880
Organism Pseudocitrobacter corydidari isolate G163CM

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag G163CM_RS06075 Protein ID WP_231827248.1
Coordinates 1326005..1327318 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag G163CM_RS06070 Protein ID WP_015964395.1
Coordinates 1325739..1326005 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G163CM_RS06065 (1325403) 1325403..1325561 + 159 WP_015964394.1 YqaE/Pmp3 family membrane protein -
G163CM_RS06070 (1325739) 1325739..1326005 + 267 WP_015964395.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
G163CM_RS06075 (1326005) 1326005..1327318 + 1314 WP_231827248.1 type II toxin-antitoxin system HipA family toxin Toxin
G163CM_RS06080 (1327504) 1327504..1328235 - 732 WP_231827249.1 hypothetical protein -
G163CM_RS06085 (1328341) 1328341..1328832 - 492 WP_231827250.1 helix-turn-helix transcriptional regulator -
G163CM_RS06090 (1329028) 1329028..1330143 + 1116 WP_231827251.1 phage/plasmid replication protein -
G163CM_RS06095 (1330158) 1330158..1330475 + 318 WP_151103012.1 DNA-binding protein -
G163CM_RS06100 (1330516) 1330516..1330785 + 270 WP_231827252.1 hypothetical protein -
G163CM_RS06105 (1330797) 1330797..1331045 + 249 WP_231827253.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48682.23 Da        Isoelectric Point: 8.5946

>T226444 WP_231827248.1 NZ_CP087880:1326005-1327318 [Pseudocitrobacter corydidari]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQVGNITSDAVFNFFDNLLPDSPIVRDRIVKRYR
AKSKQPFDLLSEVGRDSVGAVTLLPEDEAVTNPVMTWEKLSEAKLEEVLSAYKSDIPLGMINAENDFRISVAGAQEKTAL
LKMGADWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYFCLLLAKQLGLNVPGPEIIKAGRVRALAVERFDRRW
NTERSVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGRKTAIDKIYPRHFLATAKALKFPEVQMREILNEFAEQIP
AALDNVTTALPTDFPENVAMAIQTNVLRLHGRLSRER

Download         Length: 1314 bp

>T226444 NZ_CP122492:2364938-2366260 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10001.36 Da        Isoelectric Point: 4.6509

>AT226444 WP_015964395.1 NZ_CP087880:1325739-1326005 [Pseudocitrobacter corydidari]
MKSFPMIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCETKDAAPES
TDQQDLEW

Download         Length: 267 bp

>AT226444 NZ_CP122492:2364672-2364938 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References