Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2351614..2352238 Replicon chromosome
Accession NZ_CP087865
Organism Moraxella bovis strain SAM57868

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP122_RS11595 Protein ID WP_264677651.1
Coordinates 2351936..2352238 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP122_RS11590 Protein ID WP_264677652.1
Coordinates 2351614..2351949 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP122_RS11565 (LP122_11460) 2346726..2347796 + 1071 WP_115368772.1 5'-nucleotidase -
LP122_RS11570 (LP122_11465) 2348005..2348322 + 318 WP_078274423.1 H-NS histone family protein -
LP122_RS11575 (LP122_11470) 2348782..2349522 + 741 WP_112742704.1 single-stranded DNA-binding protein -
LP122_RS11580 (LP122_11475) 2349697..2350929 + 1233 WP_264677654.1 beta-ketoacyl-ACP synthase II -
LP122_RS11585 (LP122_11480) 2351117..2351581 + 465 WP_264677653.1 hypothetical protein -
LP122_RS11590 (LP122_11485) 2351614..2351949 - 336 WP_264677652.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP122_RS11595 (LP122_11490) 2351936..2352238 - 303 WP_264677651.1 type II toxin-antitoxin system HicA family toxin Toxin
LP122_RS11600 (LP122_11495) 2352376..2353731 + 1356 WP_264677650.1 anthranilate synthase component I family protein -
LP122_RS11605 (LP122_11500) 2353841..2354959 + 1119 WP_264677649.1 acyl-CoA dehydrogenase family protein -
LP122_RS11615 (LP122_11510) 2354978..2356333 + 1356 WP_272506296.1 FAD-dependent oxidoreductase -
LP122_RS11620 (LP122_11515) 2356590..2357144 - 555 WP_078274416.1 porin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(21-73)

Antitoxin

Uncharacterised protein family HicB

(52-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.89 Da        Isoelectric Point: 6.3267

>T226433 WP_264677651.1 NZ_CP087865:c2352238-2351936 [Moraxella bovis]
MTKSDKLKAKLYGDVRTFVFSDLVTLLSQLGYEMHERAGSRVVFVHCDDNSDRIHLHKPHPENTIKGGALKAVKAYLSEK
GYFDEFNDDVLNQELKNDDL

Download         Length: 303 bp

>T226433 NZ_CP122492:194056-194163 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12590.10 Da        Isoelectric Point: 4.4118

>AT226433 WP_264677652.1 NZ_CP087865:c2351949-2351614 [Moraxella bovis]
MMTYKGYVGEFTLDNDDEIFYGKLIGINQLVTFEADNAHDLKQAFYDSVDDYLAFCAEQGIEPDKPFKGSFNVRIDSELH
RRAYMASRDSSLNAFVGQAISEKLNRMAVSI

Download         Length: 336 bp

>AT226433 NZ_CP122492:c193999-193942 [Escherichia coli]
TCAAGATTAGCCCCCGTTATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References