Detailed information of TA system TA226430

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1634127..1634679
• Replicon: chromosome
• Accession: NZ_CP087865
• Organism: Moraxella bovis strain SAM57868

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP122_RS07940
• Protein ID: WP_029102268.1
• Coordinates: 1634127..1634405 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP122_RS07945
• Protein ID: WP_078273473.1
• Coordinates: 1634392..1634679 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP122_RS07910 (LP122_07830)	1630113..1630889	-	777	WP_264678118.1	nucleotidyltransferase domain-containing protein	-
LP122_RS07915 (LP122_07835)	1631002..1631352	+	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP122_RS07920 (LP122_07840)	1631500..1632015	+	516	WP_264678117.1	hypothetical protein	-
LP122_RS07925 (LP122_07845)	1632116..1632298	+	183	WP_264683628.1	hypothetical protein	-
LP122_RS07930 (LP122_07850)	1632511..1633176	+	666	WP_264678115.1	PspA/IM30 family protein	-
LP122_RS07935 (LP122_07855)	1633376..1634032	+	657	WP_264678114.1	YqiJ family protein	-
LP122_RS07940 (LP122_07860)	1634127..1634405	+	279	WP_029102268.1	BrnT family toxin	Toxin
LP122_RS07945 (LP122_07865)	1634392..1634679	+	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP122_RS07950 (LP122_07870)	1634689..1636419	+	1731	WP_078273474.1	flotillin domain-containing protein	-
LP122_RS07955	1636463..1636588	-	126	WP_264676709.1	hypothetical protein	-
LP122_RS07960 (LP122_07875)	1636617..1638137	-	1521	WP_264678113.1	DUF389 domain-containing protein	-
LP122_RS07965 (LP122_07880)	1638216..1639265	-	1050	WP_264678112.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226430 WP_029102268.1 NZ_CP087865:1634127-1634405 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226430 NZ_CP122473:61235-61717 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226430 WP_078273473.1 NZ_CP087865:1634392-1634679 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226430 NZ_CP122473:60981-61247 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3