Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1240024..1240522 Replicon chromosome
Accession NC_010380
Organism Streptococcus pneumoniae Hungary19A-6

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag SPH_RS06480 Protein ID WP_001809704.1
Coordinates 1240024..1240278 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag SPH_RS06485 Protein ID WP_000208080.1
Coordinates 1240280..1240522 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPH_RS06465 1235308..1237776 - 2469 WP_001152990.1 DNA gyrase subunit A -
SPH_RS06470 1237970..1238956 + 987 WP_000204727.1 L-lactate dehydrogenase -
SPH_RS06475 1239204..1239977 - 774 WP_000731136.1 ion transporter -
SPH_RS06480 1240024..1240278 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SPH_RS06485 1240280..1240522 - 243 WP_000208080.1 hypothetical protein Antitoxin
SPH_RS06490 1240613..1241422 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
SPH_RS06495 1241424..1242773 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
SPH_RS06500 1242766..1243470 - 705 WP_000722076.1 response regulator transcription factor -
SPH_RS06505 1243525..1244700 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T22643 WP_001809704.1 NC_010380:c1240278-1240024 [Streptococcus pneumoniae Hungary19A-6]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T22643 NC_010380:c1240278-1240024 [Streptococcus pneumoniae Hungary19A-6]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT22643 WP_000208080.1 NC_010380:c1240522-1240280 [Streptococcus pneumoniae Hungary19A-6]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT22643 NC_010380:c1240522-1240280 [Streptococcus pneumoniae Hungary19A-6]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References