Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 639623..640166 Replicon chromosome
Accession NZ_CP087865
Organism Moraxella bovis strain SAM57868

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP122_RS03060 Protein ID WP_245952240.1
Coordinates 639939..640166 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP122_RS03055 Protein ID WP_078273964.1
Coordinates 639623..639958 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP122_RS03030 (LP122_03000) 634782..635864 - 1083 WP_264677155.1 tRNA pseudouridine(13) synthase TruD -
LP122_RS03035 (LP122_03005) 635968..636402 - 435 WP_264677154.1 carbonic anhydrase family protein -
LP122_RS03040 (LP122_03010) 636414..636764 - 351 WP_264677153.1 hypothetical protein -
LP122_RS03045 (LP122_03015) 637411..638592 - 1182 WP_264678410.1 fatty acid desaturase -
LP122_RS03050 (LP122_03020) 638855..639439 + 585 Protein_581 TetR/AcrR family transcriptional regulator -
LP122_RS03055 (LP122_03025) 639623..639958 - 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP122_RS03060 (LP122_03030) 639939..640166 - 228 WP_245952240.1 hypothetical protein Toxin
LP122_RS03065 (LP122_03035) 640398..641106 + 709 Protein_584 ParA family protein -
LP122_RS03070 (LP122_03040) 641196..642581 - 1386 WP_078273966.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8451.18 Da        Isoelectric Point: 4.5519

>T226428 WP_245952240.1 NZ_CP087865:c640166-639939 [Moraxella bovis]
ISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQTHEHNDN

Download         Length: 228 bp

>T226428 NZ_CP122469:c5227232-5226849 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGAAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226428 WP_078273964.1 NZ_CP087865:c639958-639623 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226428 NZ_CP122469:c5227474-5227232 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References