Detailed information of TA system TA226425

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2350371..2350995
• Replicon: chromosome
• Accession: NZ_CP087863
• Organism: Moraxella bovis strain SAM57926

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LP089_RS11665
• Protein ID: WP_264677651.1
• Coordinates: 2350693..2350995 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LP089_RS11660
• Protein ID: WP_264677652.1
• Coordinates: 2350371..2350706 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP089_RS11635 (LP089_11555)	2345483..2346553	+	1071	WP_115368772.1	5'-nucleotidase	-
LP089_RS11640 (LP089_11560)	2346762..2347079	+	318	WP_078274423.1	H-NS histone family protein	-
LP089_RS11645 (LP089_11565)	2347539..2348279	+	741	WP_112742704.1	single-stranded DNA-binding protein	-
LP089_RS11650 (LP089_11570)	2348454..2349686	+	1233	WP_264677654.1	beta-ketoacyl-ACP synthase II	-
LP089_RS11655 (LP089_11575)	2349874..2350338	+	465	WP_264677653.1	hypothetical protein	-
LP089_RS11660 (LP089_11580)	2350371..2350706	-	336	WP_264677652.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LP089_RS11665 (LP089_11585)	2350693..2350995	-	303	WP_264677651.1	type II toxin-antitoxin system HicA family toxin	Toxin
LP089_RS11670 (LP089_11590)	2351133..2352488	+	1356	WP_264677650.1	anthranilate synthase component I family protein	-
LP089_RS11675 (LP089_11595)	2352598..2353716	+	1119	WP_264677649.1	acyl-CoA dehydrogenase family protein	-
LP089_RS11685 (LP089_11605)	2353735..2355090	+	1356	WP_272506296.1	FAD-dependent oxidoreductase	-
LP089_RS11690 (LP089_11610)	2355347..2355901	-	555	WP_078274416.1	porin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (21-73)

Antitoxin

• Uncharacterised protein family HicB (52-100)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11427.89 Da
• Isoelectric Point: 6.3267

>T226425 WP_264677651.1 NZ_CP087863:c2350995-2350693 [Moraxella bovis]
MTKSDKLKAKLYGDVRTFVFSDLVTLLSQLGYEMHERAGSRVVFVHCDDNSDRIHLHKPHPENTIKGGALKAVKAYLSEK
GYFDEFNDDVLNQELKNDDL

Nucleotide

• Length: 303 bp

>T226425 NZ_CP122469:c4664256-4663723 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12590.10 Da
• Isoelectric Point: 4.4118

>AT226425 WP_264677652.1 NZ_CP087863:c2350706-2350371 [Moraxella bovis]
MMTYKGYVGEFTLDNDDEIFYGKLIGINQLVTFEADNAHDLKQAFYDSVDDYLAFCAEQGIEPDKPFKGSFNVRIDSELH
RRAYMASRDSSLNAFVGQAISEKLNRMAVSI

Nucleotide

• Length: 336 bp

>AT226425 NZ_CP122469:c4664533-4664267 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
GGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA