Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1917606..1918255 Replicon chromosome
Accession NZ_CP087863
Organism Moraxella bovis strain SAM57926

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP089_RS09415 Protein ID WP_264677937.1
Coordinates 1917606..1918007 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP089_RS09420 Protein ID WP_112741908.1
Coordinates 1918022..1918255 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP089_RS09385 (LP089_09320) 1913259..1913432 + 174 WP_264677941.1 hypothetical protein -
LP089_RS09390 (LP089_09325) 1913684..1914103 + 420 WP_264677940.1 S4 domain-containing protein -
LP089_RS09400 (LP089_09335) 1914841..1915530 + 690 WP_264677939.1 SIMPL domain-containing protein -
LP089_RS09405 (LP089_09340) 1915630..1916460 - 831 WP_264677938.1 inositol monophosphatase family protein -
LP089_RS09410 (LP089_09345) 1916582..1917082 - 501 WP_112741909.1 WG repeat-containing protein -
LP089_RS09415 (LP089_09350) 1917606..1918007 - 402 WP_264677937.1 type II toxin-antitoxin system VapC family toxin Toxin
LP089_RS09420 (LP089_09355) 1918022..1918255 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP089_RS09425 (LP089_09360) 1918303..1920402 - 2100 WP_264683682.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP089_RS09430 (LP089_09365) 1920623..1921216 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP089_RS09435 (LP089_09370) 1921236..1922228 + 993 WP_264683684.1 oxygen-dependent coproporphyrinogen oxidase -
LP089_RS09440 (LP089_09375) 1922410..1922859 + 450 WP_264683685.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15071.29 Da        Isoelectric Point: 6.8426

>T226424 WP_264677937.1 NZ_CP087863:c1918007-1917606 [Moraxella bovis]
MFSFMLDTNICIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226424 NZ_CP122469:4043832-4044050 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226424 WP_112741908.1 NZ_CP087863:c1918255-1918022 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226424 NZ_CP122469:4043431-4043805 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACTTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References