Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) AbkB-shpB/BrnT-BrnA
Location 1635645..1636197 Replicon chromosome
Accession NZ_CP087863
Organism Moraxella bovis strain SAM57926

Toxin (Protein)


Gene name AbkB Uniprot ID A0A1T0A7D3
Locus tag LP089_RS08005 Protein ID WP_029102268.1
Coordinates 1635645..1635923 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag LP089_RS08010 Protein ID WP_078273473.1
Coordinates 1635910..1636197 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP089_RS07975 (LP089_07915) 1631631..1632407 - 777 WP_264678118.1 nucleotidyltransferase domain-containing protein -
LP089_RS07980 (LP089_07920) 1632520..1632870 + 351 WP_078273468.1 TIGR01244 family sulfur transferase -
LP089_RS07985 (LP089_07925) 1633018..1633533 + 516 WP_264678117.1 hypothetical protein -
LP089_RS07990 (LP089_07930) 1633634..1633816 + 183 WP_264683628.1 hypothetical protein -
LP089_RS07995 (LP089_07935) 1634029..1634694 + 666 WP_264678115.1 PspA/IM30 family protein -
LP089_RS08000 (LP089_07940) 1634894..1635550 + 657 WP_264678114.1 YqiJ family protein -
LP089_RS08005 (LP089_07945) 1635645..1635923 + 279 WP_029102268.1 BrnT family toxin Toxin
LP089_RS08010 (LP089_07950) 1635910..1636197 + 288 WP_078273473.1 BrnA antitoxin family protein Antitoxin
LP089_RS08015 (LP089_07955) 1636207..1637937 + 1731 WP_078273474.1 flotillin domain-containing protein -
LP089_RS08020 (LP089_07960) 1638135..1639655 - 1521 WP_264678113.1 DUF389 domain-containing protein -
LP089_RS08025 (LP089_07965) 1639734..1640783 - 1050 WP_264678112.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-85)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(36-89)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10484.81 Da        Isoelectric Point: 5.1084

>T226422 WP_029102268.1 NZ_CP087863:1635645-1635923 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Download         Length: 279 bp

>T226422 NZ_CP122469:1807033-1807135 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10979.71 Da        Isoelectric Point: 7.0097

>AT226422 WP_078273473.1 NZ_CP087863:1635910-1636197 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Download         Length: 288 bp

>AT226422 NZ_CP122469:c1807142-1806997 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1T0A7D3

Antitoxin

Source ID Structure

References