Detailed information of TA system TA226421

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1164742..1165231
• Replicon: chromosome
• Accession: NZ_CP087863
• Organism: Moraxella bovis strain SAM57926

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP089_RS05645
• Protein ID: WP_264676856.1
• Coordinates: 1164974..1165231 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LP089_RS05640
• Protein ID: WP_228157840.1
• Coordinates: 1164742..1164984 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP089_RS05605 (LP089_05575)	1159833..1160882	+	1050	WP_264676261.1	RluA family pseudouridine synthase	-
LP089_RS05610 (LP089_05580)	1161001..1161798	+	798	WP_264676861.1	polyphenol oxidase family protein	-
LP089_RS05615 (LP089_05585)	1161795..1162403	+	609	WP_264684677.1	bestrophin family protein	-
LP089_RS05620	1162684..1163207	+	524	Protein_1087	DUF853 family protein	-
LP089_RS05625 (LP089_05590)	1163194..1164141	+	948	WP_264676857.1	DUF853 domain-containing protein	-
LP089_RS05630 (LP089_05595)	1164164..1164451	+	288	WP_115005096.1	DUF1315 family protein	-
LP089_RS05635 (LP089_05600)	1164533..1164697	-	165	WP_158079593.1	hypothetical protein	-
LP089_RS05640 (LP089_05605)	1164742..1164984	+	243	WP_228157840.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LP089_RS05645 (LP089_05610)	1164974..1165231	+	258	WP_264676856.1	Txe/YoeB family addiction module toxin	Toxin
LP089_RS05650 (LP089_05615)	1165290..1165799	+	510	WP_264676855.1	peptidylprolyl isomerase	-
LP089_RS05655 (LP089_05620)	1165866..1166669	+	804	WP_264676854.1	UDP-2,3-diacylglucosamine diphosphatase	-
LP089_RS05660 (LP089_05625)	1166766..1169252	-	2487	WP_264676853.1	alpha/beta hydrolase	-
LP089_RS05665 (LP089_05630)	1169355..1170203	-	849	WP_264676852.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-68)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10488.00 Da
• Isoelectric Point: 8.1158

>T226421 WP_264676856.1 NZ_CP087863:1164974-1165231 [Moraxella bovis]
MRIRWFDEVWEDYLYWQSQDKKTIKRINTLIKDCRRDPFDGIGKPEPLKYNLTGYWLRRINDANRLVYCCESETLIISCR
HHYEA

Nucleotide

• Length: 258 bp

>T226421 NZ_CP122469:792216-792626 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9134.23 Da
• Isoelectric Point: 6.2120

>AT226421 WP_228157840.1 NZ_CP087863:1164742-1164984 [Moraxella bovis]
MNYSEFRQNLASALDYVQDSHAPVIVKRGKHSAVVISLDEYNAFKETDYLLSNPANAEHLMRGVQAVKNRQLTQRDLIED

Nucleotide

• Length: 243 bp

>AT226421 NZ_CP122469:791969-792235 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA