Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 638444..639020 Replicon chromosome
Accession NZ_CP087863
Organism Moraxella bovis strain SAM57926

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP089_RS03100 Protein ID WP_264676341.1
Coordinates 638760..639020 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP089_RS03095 Protein ID WP_078273964.1
Coordinates 638444..638779 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP089_RS03070 (LP089_03055) 633604..634686 - 1083 WP_264677155.1 tRNA pseudouridine(13) synthase TruD -
LP089_RS03075 (LP089_03060) 634790..635224 - 435 WP_264677154.1 carbonic anhydrase family protein -
LP089_RS03080 (LP089_03065) 635236..635586 - 351 WP_264677153.1 hypothetical protein -
LP089_RS03085 (LP089_03070) 636233..637372 - 1140 WP_264690182.1 fatty acid desaturase -
LP089_RS03090 (LP089_03075) 637676..638260 + 585 Protein_591 TetR/AcrR family transcriptional regulator -
LP089_RS03095 (LP089_03080) 638444..638779 - 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP089_RS03100 (LP089_03085) 638760..639020 - 261 WP_264676341.1 type II toxin-antitoxin system HicA family toxin Toxin
LP089_RS03105 (LP089_03090) 639219..639927 + 709 Protein_594 ParA family protein -
LP089_RS03110 (LP089_03095) 640017..641402 - 1386 WP_078273966.1 APC family permease -
LP089_RS03115 (LP089_03100) 641914..643989 - 2076 WP_264677152.1 NAD-dependent DNA ligase LigA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9551.46 Da        Isoelectric Point: 4.3376

>T226420 WP_264676341.1 NZ_CP087863:c639020-638760 [Moraxella bovis]
IEALFVALGADISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQT
HEHNDN

Download         Length: 261 bp

>T226420 NZ_CP122469:356138-356485 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226420 WP_078273964.1 NZ_CP087863:c638779-638444 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226420 NZ_CP122469:356485-356778 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAAGTCTCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References