Detailed information of TA system TA022642

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1171260..1172494
• Replicon: chromosome
• Accession: NC_010380
• Organism: Streptococcus pneumoniae Hungary19A-6

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: E6Y3Z8
• Locus tag: SPH_RS06115
• Protein ID: WP_000405369.1
• Coordinates: 1171736..1172494 (+)
• Length: 253 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: SPH_RS06110
• Protein ID: WP_000579597.1
• Coordinates: 1171260..1171736 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPH_RS06075	1166468..1166866	+	399	WP_000351508.1	hypothetical protein	-
SPH_RS11990	1167194..1168075	+	882	WP_000451090.1	GIY-YIG nuclease family protein	-
SPH_RS06085	1168479..1169120	+	642	WP_000933082.1	hypothetical protein	-
SPH_RS06090	1169130..1170215	+	1086	WP_000401897.1	toprim domain-containing protein	-
SPH_RS06095	1170266..1170499	+	234	WP_000152419.1	hypothetical protein	-
SPH_RS06100	1170496..1170879	+	384	WP_000159215.1	hypothetical protein	-
SPH_RS06105	1170917..1171189	+	273	WP_000495448.1	hypothetical protein	-
SPH_RS06110	1171260..1171736	+	477	WP_000579597.1	helix-turn-helix domain-containing protein	Antitoxin
SPH_RS06115	1171736..1172494	+	759	WP_000405369.1	zeta toxin family protein	Toxin
SPH_RS06120	1172970..1173758	+	789	WP_000214003.1	hypothetical protein	-
SPH_RS06125	1173997..1174245	+	249	WP_001814254.1	hypothetical protein	-
SPH_RS06130	1174416..1175135	+	720	Protein_1171	type A chloramphenicol O-acetyltransferase	-
SPH_RS06135	1175931..1176854	-	924	WP_000417606.1	protein rep	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	cat(pC194)	-	1028133..1197472	169339

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 253 a.a.
• Molecular weight: 28911.84 Da
• Isoelectric Point: 7.5459

>T22642 WP_000405369.1 NC_010380:1171736-1172494 [Streptococcus pneumoniae Hungary19A-6]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN

Nucleotide

• Length: 759 bp

>T22642 NC_010380:1171736-1172494 [Streptococcus pneumoniae Hungary19A-6]
GTGGAAATCCAAGATTATACTGACAGTGAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTCGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGAGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTTCAGCAA
GAATATGGCAAAGACAGTGTTGAATACACCAAATATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAAGAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACTATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAGTA
GGGGATATGAAATACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTACGCTATTAACCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAGGTTGTGTATATGATGCAA
AAGAAAATACAACTTCAGCGGCAGATGTTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAAGTAGAGAAGGATATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATTGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18235.60 Da
• Isoelectric Point: 4.3571

>AT22642 WP_000579597.1 NC_010380:1171260-1171736 [Streptococcus pneumoniae Hungary19A-6]
MIGKNIKSLRKTHDLTQDDFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT22642 NC_010380:1171260-1171736 [Streptococcus pneumoniae Hungary19A-6]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAAGACGACTTTGCCCGAATTGTAGGAATTTC
TCGAAATAGCTTGAGCCGGTATGAAAATGGAACGAGTTCAGTCTCTACGGAACTAATAGATATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTGAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGAGCTAATCTATTATCACGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAG

Structures

Toxin

• AlphaFold DB: E6Y3Z8