Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 361020..361672 Replicon chromosome
Accession NZ_CP087863
Organism Moraxella bovis strain SAM57926

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP089_RS01705 Protein ID WP_264690159.1
Coordinates 361280..361672 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP089_RS01700 Protein ID WP_264675982.1
Coordinates 361020..361283 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP089_RS01660 (LP089_01630) 356099..356302 + 204 WP_115368689.1 hypothetical protein -
LP089_RS01665 (LP089_01635) 356422..357756 + 1335 WP_264677331.1 deoxyguanosinetriphosphate triphosphohydrolase -
LP089_RS01670 (LP089_01640) 357900..358193 + 294 WP_264677330.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP089_RS01675 (LP089_01645) 358186..358458 + 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP089_RS01680 (LP089_01650) 358523..358978 - 456 WP_264677329.1 type IV secretion protein Rhs -
LP089_RS01685 (LP089_01655) 359038..359307 + 270 WP_264677328.1 hypothetical protein -
LP089_RS01690 (LP089_01660) 359304..359684 + 381 WP_264677327.1 type II toxin-antitoxin system VapC family toxin -
LP089_RS01695 (LP089_01665) 359681..360940 + 1260 WP_264677326.1 replication-associated recombination protein A -
LP089_RS01700 (LP089_01670) 361020..361283 + 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP089_RS01705 (LP089_01675) 361280..361672 + 393 WP_264690159.1 type II toxin-antitoxin system VapC family toxin Toxin
LP089_RS01710 (LP089_01680) 361795..362325 + 531 WP_264678418.1 glucose-6-phosphate 1-dehydrogenase family protein -
LP089_RS01715 (LP089_01685) 362322..362888 - 567 WP_078275186.1 hypothetical protein -
LP089_RS01720 (LP089_01690) 362891..363127 - 237 WP_078275185.1 sulfurtransferase TusA -
LP089_RS01725 (LP089_01695) 363124..363582 - 459 WP_264677324.1 acyl-CoA thioesterase -
LP089_RS01730 (LP089_01700) 363661..364683 - 1023 WP_264677323.1 hypothetical protein -
LP089_RS01735 (LP089_01705) 364714..365592 - 879 WP_264677322.1 uroporphyrinogen-III synthase -
LP089_RS01740 (LP089_01710) 365638..366579 - 942 WP_078275181.1 hydroxymethylbilane synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14602.67 Da        Isoelectric Point: 4.7370

>T226419 WP_264690159.1 NZ_CP087863:361280-361672 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGSYDTLIAGQAIANDLIVITDNVREFLRVDGLQIESWLK

Download         Length: 393 bp

>T226419 NZ_CP122469:330167-330535 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226419 WP_264675982.1 NZ_CP087863:361020-361283 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226419 NZ_CP122469:329949-330170 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References