Detailed information of TA system TA226418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 357900..358458
• Replicon: chromosome
• Accession: NZ_CP087863
• Organism: Moraxella bovis strain SAM57926

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP089_RS01675
• Protein ID: WP_228157760.1
• Coordinates: 358186..358458 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LP089_RS01670
• Protein ID: WP_264677330.1
• Coordinates: 357900..358193 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP089_RS01645 (LP089_01615)	353616..354920	-	1305	WP_264677332.1	valine--pyruvate transaminase	-
LP089_RS01650 (LP089_01620)	355041..355652	+	612	WP_115368690.1	methyltransferase	-
LP089_RS01655 (LP089_01625)	355759..356109	+	351	WP_181879486.1	PIN domain protein	-
LP089_RS01660 (LP089_01630)	356099..356302	+	204	WP_115368689.1	hypothetical protein	-
LP089_RS01665 (LP089_01635)	356422..357756	+	1335	WP_264677331.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP089_RS01670 (LP089_01640)	357900..358193	+	294	WP_264677330.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP089_RS01675 (LP089_01645)	358186..358458	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP089_RS01680 (LP089_01650)	358523..358978	-	456	WP_264677329.1	type IV secretion protein Rhs	-
LP089_RS01685 (LP089_01655)	359038..359307	+	270	WP_264677328.1	hypothetical protein	-
LP089_RS01690 (LP089_01660)	359304..359684	+	381	WP_264677327.1	type II toxin-antitoxin system VapC family toxin	-
LP089_RS01695 (LP089_01665)	359681..360940	+	1260	WP_264677326.1	replication-associated recombination protein A	-
LP089_RS01700 (LP089_01670)	361020..361283	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP089_RS01705 (LP089_01675)	361280..361672	+	393	WP_264690159.1	type II toxin-antitoxin system VapC family toxin	-
LP089_RS01710 (LP089_01680)	361795..362325	+	531	WP_264678418.1	glucose-6-phosphate 1-dehydrogenase family protein	-
LP089_RS01715 (LP089_01685)	362322..362888	-	567	WP_078275186.1	hypothetical protein	-
LP089_RS01720 (LP089_01690)	362891..363127	-	237	WP_078275185.1	sulfurtransferase TusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-52)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226418 WP_228157760.1 NZ_CP087863:358186-358458 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226418 NZ_CP122463:63225-63530 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11096.37 Da
• Isoelectric Point: 4.7769

>AT226418 WP_264677330.1 NZ_CP087863:357900-358193 [Moraxella bovis]
MSHTNFNMRLDNDLRQKVYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226418 NZ_CP122463:63005-63223 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCGGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGATATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA