Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2185598..2186250 Replicon chromosome
Accession NZ_CP087862
Organism Moraxella bovis strain SAM57979

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP105_RS11040 Protein ID WP_264677325.1
Coordinates 2185598..2185990 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP105_RS11045 Protein ID WP_264675982.1
Coordinates 2185987..2186250 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP105_RS11005 (LP105_10940) 2180691..2181632 + 942 WP_078275181.1 hydroxymethylbilane synthase -
LP105_RS11010 (LP105_10945) 2181678..2182556 + 879 WP_264677322.1 uroporphyrinogen-III synthase -
LP105_RS11015 (LP105_10950) 2182587..2183609 + 1023 WP_264677323.1 hypothetical protein -
LP105_RS11020 (LP105_10955) 2183688..2184146 + 459 WP_264677324.1 acyl-CoA thioesterase -
LP105_RS11025 (LP105_10960) 2184143..2184379 + 237 WP_078275185.1 sulfurtransferase TusA -
LP105_RS11030 (LP105_10965) 2184382..2184948 + 567 WP_078275186.1 hypothetical protein -
LP105_RS11035 (LP105_10970) 2184945..2185475 - 531 WP_264678418.1 glucose-6-phosphate 1-dehydrogenase family protein -
LP105_RS11040 (LP105_10975) 2185598..2185990 - 393 WP_264677325.1 type II toxin-antitoxin system VapC family toxin Toxin
LP105_RS11045 (LP105_10980) 2185987..2186250 - 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP105_RS11050 (LP105_10985) 2186330..2187589 - 1260 WP_264677326.1 replication-associated recombination protein A -
LP105_RS11055 (LP105_10990) 2187586..2187966 - 381 WP_264677327.1 type II toxin-antitoxin system VapC family toxin -
LP105_RS11060 (LP105_10995) 2187963..2188232 - 270 WP_264677328.1 hypothetical protein -
LP105_RS11065 (LP105_11000) 2188292..2188747 + 456 WP_264677329.1 type IV secretion protein Rhs -
LP105_RS11070 (LP105_11005) 2188812..2189084 - 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP105_RS11075 (LP105_11010) 2189077..2189370 - 294 WP_264677330.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP105_RS11080 (LP105_11015) 2189514..2190848 - 1335 WP_264677331.1 deoxyguanosinetriphosphate triphosphohydrolase -
LP105_RS11085 (LP105_11020) 2190968..2191171 - 204 WP_115368689.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14629.69 Da        Isoelectric Point: 4.7370

>T226416 WP_264677325.1 NZ_CP087862:c2185990-2185598 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGSYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226416 NZ_CP122461:c5226193-5225810 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGAAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226416 WP_264675982.1 NZ_CP087862:c2186250-2185987 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226416 NZ_CP122461:c5226435-5226193 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References