Detailed information of TA system TA226414

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1390207..1390696
• Replicon: chromosome
• Accession: NZ_CP087862
• Organism: Moraxella bovis strain SAM57979

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP105_RS07120
• Protein ID: WP_264676856.1
• Coordinates: 1390207..1390464 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LP105_RS07125
• Protein ID: WP_228157840.1
• Coordinates: 1390454..1390696 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP105_RS07100 (LP105_07050)	1385235..1386083	+	849	WP_264676852.1	hypothetical protein	-
LP105_RS07105 (LP105_07055)	1386186..1388672	+	2487	WP_264676853.1	alpha/beta hydrolase	-
LP105_RS07110 (LP105_07060)	1388769..1389572	-	804	WP_264676854.1	UDP-2,3-diacylglucosamine diphosphatase	-
LP105_RS07115 (LP105_07065)	1389639..1390148	-	510	WP_264676855.1	peptidylprolyl isomerase	-
LP105_RS07120 (LP105_07070)	1390207..1390464	-	258	WP_264676856.1	Txe/YoeB family addiction module toxin	Toxin
LP105_RS07125 (LP105_07075)	1390454..1390696	-	243	WP_228157840.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LP105_RS07130 (LP105_07080)	1390741..1390905	+	165	WP_158079593.1	hypothetical protein	-
LP105_RS07135 (LP105_07085)	1390987..1391274	-	288	WP_115005096.1	DUF1315 family protein	-
LP105_RS07140 (LP105_07090)	1391297..1392244	-	948	WP_264676857.1	DUF853 domain-containing protein	-
LP105_RS07145 (LP105_07095)	1392231..1392647	-	417	WP_264676858.1	DUF853 domain-containing protein	-
LP105_RS07150 (LP105_07100)	1392560..1392817	-	258	WP_264676404.1	DUF853 domain-containing protein	-
LP105_RS07155 (LP105_07105)	1393035..1393643	-	609	WP_264684677.1	bestrophin family protein	-
LP105_RS07160 (LP105_07110)	1393640..1394437	-	798	WP_264676861.1	polyphenol oxidase family protein	-
LP105_RS07165 (LP105_07115)	1394556..1395605	-	1050	WP_264676261.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-68)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10488.00 Da
• Isoelectric Point: 8.1158

>T226414 WP_264676856.1 NZ_CP087862:c1390464-1390207 [Moraxella bovis]
MRIRWFDEVWEDYLYWQSQDKKTIKRINTLIKDCRRDPFDGIGKPEPLKYNLTGYWLRRINDANRLVYCCESETLIISCR
HHYEA

Nucleotide

• Length: 258 bp

>T226414 NZ_CP122461:c4748252-4747968 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9134.23 Da
• Isoelectric Point: 6.2120

>AT226414 WP_228157840.1 NZ_CP087862:c1390696-1390454 [Moraxella bovis]
MNYSEFRQNLASALDYVQDSHAPVIVKRGKHSAVVISLDEYNAFKETDYLLSNPANAEHLMRGVQAVKNRQLTQRDLIED

Nucleotide

• Length: 243 bp

>AT226414 NZ_CP122461:c4748484-4748242 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA