Detailed information of TA system TA226413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 920810..921362
• Replicon: chromosome
• Accession: NZ_CP087862
• Organism: Moraxella bovis strain SAM57979

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP105_RS04790
• Protein ID: WP_029102268.1
• Coordinates: 921084..921362 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP105_RS04785
• Protein ID: WP_078273473.1
• Coordinates: 920810..921097 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP105_RS04765 (LP105_04745)	916224..917273	+	1050	WP_264678112.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
LP105_RS04770 (LP105_04750)	917352..918872	+	1521	WP_264678113.1	DUF389 domain-containing protein	-
LP105_RS04775	918901..919026	+	126	WP_264676709.1	hypothetical protein	-
LP105_RS04780 (LP105_04755)	919070..920800	-	1731	WP_078273474.1	flotillin domain-containing protein	-
LP105_RS04785 (LP105_04760)	920810..921097	-	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP105_RS04790 (LP105_04765)	921084..921362	-	279	WP_029102268.1	BrnT family toxin	Toxin
LP105_RS04795 (LP105_04770)	921457..922113	-	657	WP_264678114.1	YqiJ family protein	-
LP105_RS04800 (LP105_04775)	922313..922978	-	666	WP_264678115.1	PspA/IM30 family protein	-
LP105_RS04805 (LP105_04780)	923191..923373	-	183	WP_264683628.1	hypothetical protein	-
LP105_RS04810 (LP105_04785)	923474..923989	-	516	WP_264678117.1	hypothetical protein	-
LP105_RS04815 (LP105_04790)	924137..924487	-	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP105_RS04820 (LP105_04795)	924600..925376	+	777	WP_264678118.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226413 WP_029102268.1 NZ_CP087862:c921362-921084 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226413 NZ_CP122461:c4663217-4662684 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226413 WP_078273473.1 NZ_CP087862:c921097-920810 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226413 NZ_CP122461:c4663494-4663228 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
GGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3