Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 758411..758988 Replicon chromosome
Accession NZ_CP087862
Organism Moraxella bovis strain SAM57979

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LP105_RS04055 Protein ID WP_078275234.1
Coordinates 758653..758988 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LP105_RS04050 Protein ID WP_078275235.1
Coordinates 758411..758653 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP105_RS04030 (LP105_04005) 754031..754753 + 723 WP_264678018.1 tRNA pseudouridine(65) synthase TruC -
LP105_RS04035 (LP105_04010) 755001..755963 - 963 Protein_792 RNA-guided endonuclease TnpB family protein -
LP105_RS04040 (LP105_04015) 756173..756785 - 613 Protein_793 IS607 family transposase -
LP105_RS04045 (LP105_04020) 757125..758204 - 1080 WP_264678019.1 3-deoxy-7-phosphoheptulonate synthase -
LP105_RS04050 (LP105_04025) 758411..758653 + 243 WP_078275235.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LP105_RS04055 (LP105_04030) 758653..758988 + 336 WP_078275234.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP105_RS04060 (LP105_04035) 759050..760045 + 996 WP_208624081.1 polyprenyl synthetase family protein -
LP105_RS04065 (LP105_04040) 760069..760305 + 237 WP_264678020.1 hypothetical protein -
LP105_RS04070 (LP105_04045) 760395..762539 - 2145 WP_264678021.1 cation-translocating P-type ATPase -
LP105_RS04075 (LP105_04050) 762704..763288 - 585 WP_264684517.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-63)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13059.98 Da        Isoelectric Point: 8.8194

>T226412 WP_078275234.1 NZ_CP087862:758653-758988 [Moraxella bovis]
MCELMYELEFDERALKEWQKLGDTIKTQFKKRLAKVLKNPHIIANRLSGGQNLYKINFRSAGYRLVYQVEDDKVVVFVIV
MGKREKNAVYDTAEEWLAERQSDNQDTQSVK

Download         Length: 336 bp

>T226412 NZ_CP122461:4042813-4043031 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9034.47 Da        Isoelectric Point: 4.7527

>AT226412 WP_078275235.1 NZ_CP087862:758411-758653 [Moraxella bovis]
MANIVARVDDDLKAQSFLVLQELGVTPSELIRQTLQYVAYHKKLPFKTVVLTDEDSELLALAKERLDNPAPRIKVSLDEL

Download         Length: 243 bp

>AT226412 NZ_CP122461:4042412-4042786 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACTTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References