Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 188869..189493 Replicon chromosome
Accession NZ_CP087862
Organism Moraxella bovis strain SAM57979

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP105_RS01040 Protein ID WP_264677651.1
Coordinates 188869..189171 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP105_RS01045 Protein ID WP_264677652.1
Coordinates 189158..189493 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP105_RS01015 (LP105_01010) 183963..184517 + 555 WP_078274416.1 porin family protein -
LP105_RS01020 (LP105_01015) 184774..186129 - 1356 WP_272506296.1 FAD-dependent oxidoreductase -
LP105_RS01030 (LP105_01025) 186148..187266 - 1119 WP_264677649.1 acyl-CoA dehydrogenase family protein -
LP105_RS01035 (LP105_01030) 187376..188731 - 1356 WP_264677650.1 anthranilate synthase component I family protein -
LP105_RS01040 (LP105_01035) 188869..189171 + 303 WP_264677651.1 type II toxin-antitoxin system HicA family toxin Toxin
LP105_RS01045 (LP105_01040) 189158..189493 + 336 WP_264677652.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP105_RS01050 (LP105_01045) 189526..189990 - 465 WP_264677653.1 hypothetical protein -
LP105_RS01055 (LP105_01050) 190178..191410 - 1233 WP_264677654.1 beta-ketoacyl-ACP synthase II -
LP105_RS01060 (LP105_01055) 191585..192325 - 741 WP_112742704.1 single-stranded DNA-binding protein -
LP105_RS01065 (LP105_01060) 192785..193102 - 318 WP_264695225.1 H-NS histone family protein -
LP105_RS01070 (LP105_01065) 193311..194381 - 1071 WP_115368772.1 5'-nucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(21-73)

Antitoxin

Uncharacterised protein family HicB

(52-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.89 Da        Isoelectric Point: 6.3267

>T226409 WP_264677651.1 NZ_CP087862:188869-189171 [Moraxella bovis]
MTKSDKLKAKLYGDVRTFVFSDLVTLLSQLGYEMHERAGSRVVFVHCDDNSDRIHLHKPHPENTIKGGALKAVKAYLSEK
GYFDEFNDDVLNQELKNDDL

Download         Length: 303 bp

>T226409 NZ_CP122461:792383-792793 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12590.10 Da        Isoelectric Point: 4.4118

>AT226409 WP_264677652.1 NZ_CP087862:189158-189493 [Moraxella bovis]
MMTYKGYVGEFTLDNDDEIFYGKLIGINQLVTFEADNAHDLKQAFYDSVDDYLAFCAEQGIEPDKPFKGSFNVRIDSELH
RRAYMASRDSSLNAFVGQAISEKLNRMAVSI

Download         Length: 336 bp

>AT226409 NZ_CP122461:792136-792402 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References