Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2256414..2257072 Replicon chromosome
Accession NZ_CP087859
Organism Moraxella bovis strain SAM57983

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP093_RS11470 Protein ID WP_078274940.1
Coordinates 2256884..2257072 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP093_RS11465 Protein ID WP_112741846.1
Coordinates 2256414..2256821 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP093_RS11435 (LP093_11335) 2251645..2253474 - 1830 WP_078274936.1 hypothetical protein -
LP093_RS11440 (LP093_11340) 2253462..2253806 - 345 WP_078274937.1 hypothetical protein -
LP093_RS11445 (LP093_11345) 2253807..2254613 - 807 WP_112741850.1 hypothetical protein -
LP093_RS11450 (LP093_11350) 2254667..2255104 - 438 WP_162860346.1 hypothetical protein -
LP093_RS11455 (LP093_11355) 2255038..2255370 - 333 WP_112741848.1 hypothetical protein -
LP093_RS11460 (LP093_11360) 2255367..2256338 - 972 WP_112741847.1 phage tail tape measure protein -
LP093_RS11465 (LP093_11365) 2256414..2256821 - 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP093_RS11470 (LP093_11370) 2256884..2257072 - 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP093_RS11475 (LP093_11375) 2257215..2257430 - 216 WP_078274941.1 hypothetical protein -
LP093_RS11480 (LP093_11380) 2257432..2258031 - 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP093_RS11485 (LP093_11385) 2258138..2258344 - 207 WP_264676102.1 DNA-binding protein -
LP093_RS11490 (LP093_11390) 2258467..2258811 + 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP093_RS11495 (LP093_11395) 2258855..2259607 - 753 WP_078274945.1 hypothetical protein -
LP093_RS11500 (LP093_11400) 2259685..2259885 - 201 WP_264676324.1 hypothetical protein -
LP093_RS11505 (LP093_11405) 2259894..2260085 - 192 WP_264676101.1 DNA-binding protein -
LP093_RS11510 (LP093_11410) 2260100..2260309 - 210 WP_078274960.1 hypothetical protein -
LP093_RS11515 (LP093_11415) 2260474..2260773 + 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP093_RS11520 (LP093_11420) 2260968..2261255 + 288 WP_078274962.1 ORF6C domain-containing protein -
LP093_RS11525 (LP093_11425) 2261252..2261671 + 420 WP_112741841.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2247177..2261671 14494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226408 WP_078274940.1 NZ_CP087859:c2257072-2256884 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226408 NZ_CP122461:356305-356652 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226408 WP_112741846.1 NZ_CP087859:c2256821-2256414 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226408 NZ_CP122461:356652-356945 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAAGTCTCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References