Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2096030..2096679 Replicon chromosome
Accession NZ_CP087859
Organism Moraxella bovis strain SAM57983

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP093_RS10660 Protein ID WP_078274052.1
Coordinates 2096030..2096431 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP093_RS10665 Protein ID WP_112741908.1
Coordinates 2096446..2096679 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP093_RS10625 (LP093_10525) 2091686..2091919 + 234 WP_112741910.1 ASCH domain-containing protein -
LP093_RS10630 (LP093_10530) 2091965..2092114 + 150 WP_162860355.1 hypothetical protein -
LP093_RS10635 (LP093_10535) 2092111..2092530 + 420 WP_078274047.1 S4 domain-containing protein -
LP093_RS10645 (LP093_10545) 2093266..2093955 + 690 WP_078274049.1 SIMPL domain-containing protein -
LP093_RS10650 (LP093_10550) 2094054..2094884 - 831 WP_078274050.1 inositol monophosphatase family protein -
LP093_RS10655 (LP093_10555) 2095006..2095506 - 501 WP_112741909.1 WG repeat-containing protein -
LP093_RS10660 (LP093_10560) 2096030..2096431 - 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP093_RS10665 (LP093_10565) 2096446..2096679 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP093_RS10670 (LP093_10570) 2096727..2098826 - 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP093_RS10675 (LP093_10575) 2099047..2099640 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP093_RS10680 (LP093_10580) 2099660..2100652 + 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP093_RS10685 (LP093_10585) 2100834..2101283 + 450 WP_264676133.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226407 WP_078274052.1 NZ_CP087859:c2096431-2096030 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226407 NZ_CP122461:330334-330702 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226407 WP_112741908.1 NZ_CP087859:c2096679-2096446 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226407 NZ_CP122461:330116-330337 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References