Detailed information of TA system TA226406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1991339..1991916
• Replicon: chromosome
• Accession: NZ_CP087859
• Organism: Moraxella bovis strain SAM57983

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP093_RS10035
• Protein ID: WP_078275234.1
• Coordinates: 1991339..1991674 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LP093_RS10040
• Protein ID: WP_078275235.1
• Coordinates: 1991674..1991916 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP093_RS10010 (LP093_09915)	1986679..1986879	+	201	WP_112741955.1	hypothetical protein	-
LP093_RS10015 (LP093_09920)	1987039..1987623	+	585	WP_112741954.1	hypothetical protein	-
LP093_RS10020 (LP093_09925)	1987788..1989932	+	2145	WP_264676147.1	cation-translocating P-type ATPase	-
LP093_RS10025 (LP093_09930)	1990022..1990210	-	189	WP_143821748.1	hypothetical protein	-
LP093_RS10030 (LP093_09935)	1990282..1991277	-	996	WP_208624081.1	polyprenyl synthetase family protein	-
LP093_RS10035 (LP093_09940)	1991339..1991674	-	336	WP_078275234.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP093_RS10040 (LP093_09945)	1991674..1991916	-	243	WP_078275235.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP093_RS10045 (LP093_09950)	1992123..1993202	+	1080	WP_029103111.1	3-deoxy-7-phosphoheptulonate synthase	-
LP093_RS10050 (LP093_09955)	1993584..1994306	-	723	WP_078275236.1	tRNA pseudouridine(65) synthase TruC	-
LP093_RS10055 (LP093_09960)	1994495..1995121	+	627	WP_078275237.1	septation protein IspZ	-
LP093_RS10060 (LP093_09965)	1995281..1995586	+	306	WP_078275238.1	YciI family protein	-
LP093_RS10065 (LP093_09970)	1995595..1996017	+	423	WP_078275239.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-63)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13059.98 Da
• Isoelectric Point: 8.8194

>T226406 WP_078275234.1 NZ_CP087859:c1991674-1991339 [Moraxella bovis]
MCELMYELEFDERALKEWQKLGDTIKTQFKKRLAKVLKNPHIIANRLSGGQNLYKINFRSAGYRLVYQVEDDKVVVFVIV
MGKREKNAVYDTAEEWLAERQSDNQDTQSVK

Nucleotide

• Length: 336 bp

>T226406 NZ_CP122460:c1242122-1241376 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTGAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9034.47 Da
• Isoelectric Point: 4.7527

>AT226406 WP_078275235.1 NZ_CP087859:c1991916-1991674 [Moraxella bovis]
MANIVARVDDDLKAQSFLVLQELGVTPSELIRQTLQYVAYHKKLPFKTVVLTDEDSELLALAKERLDNPAPRIKVSLDEL

Nucleotide

• Length: 243 bp

>AT226406 NZ_CP122460:c1241375-1241205 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA