Detailed information of TA system TA226404

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1769351..1769903
• Replicon: chromosome
• Accession: NZ_CP087859
• Organism: Moraxella bovis strain SAM57983

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP093_RS08830
• Protein ID: WP_029102268.1
• Coordinates: 1769351..1769629 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP093_RS08835
• Protein ID: WP_078273473.1
• Coordinates: 1769616..1769903 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP093_RS08800 (LP093_08715)	1765338..1766114	-	777	WP_264676230.1	nucleotidyltransferase domain-containing protein	-
LP093_RS08805 (LP093_08720)	1766226..1766576	+	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP093_RS08810 (LP093_08725)	1766724..1767239	+	516	WP_115369660.1	hypothetical protein	-
LP093_RS08815 (LP093_08730)	1767340..1767522	+	183	WP_264683628.1	hypothetical protein	-
LP093_RS08820 (LP093_08735)	1767735..1768400	+	666	WP_078273471.1	PspA/IM30 family protein	-
LP093_RS08825 (LP093_08740)	1768600..1769256	+	657	WP_078273472.1	YqiJ family protein	-
LP093_RS08830 (LP093_08745)	1769351..1769629	+	279	WP_029102268.1	BrnT family toxin	Toxin
LP093_RS08835 (LP093_08750)	1769616..1769903	+	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP093_RS08840 (LP093_08755)	1769913..1771643	+	1731	WP_078273474.1	flotillin domain-containing protein	-
LP093_RS08845	1771687..1771812	-	126	WP_264676709.1	hypothetical protein	-
LP093_RS08850 (LP093_08760)	1771841..1773340	-	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP093_RS08855 (LP093_08765)	1773419..1774468	-	1050	WP_264676228.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226404 WP_029102268.1 NZ_CP087859:1769351-1769629 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226404 NZ_CP122457:4582703-4583014 [Salmonella enterica subsp. enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226404 WP_078273473.1 NZ_CP087859:1769616-1769903 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226404 NZ_CP122457:4583011-4583457 [Salmonella enterica subsp. enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3