Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1428728..1429385 Replicon chromosome
Accession NZ_CP087859
Organism Moraxella bovis strain SAM57983

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP093_RS07000 Protein ID WP_264676287.1
Coordinates 1428728..1428910 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP093_RS07005 Protein ID WP_264676286.1
Coordinates 1428972..1429385 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP093_RS06975 (LP093_06905) 1424701..1426098 - 1398 WP_264676292.1 phage terminase large subunit -
LP093_RS06980 (LP093_06910) 1426098..1426637 - 540 WP_264676291.1 terminase small subunit -
LP093_RS06985 (LP093_06915) 1426751..1426960 + 210 WP_264676290.1 hypothetical protein -
LP093_RS06990 (LP093_06920) 1426997..1427197 + 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP093_RS06995 (LP093_06925) 1427624..1428328 - 705 WP_264676288.1 BRO family protein -
LP093_RS07000 (LP093_06930) 1428728..1428910 + 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP093_RS07005 (LP093_06935) 1428972..1429385 + 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP093_RS07010 (LP093_06940) 1429396..1429797 - 402 WP_264676285.1 antiterminator Q family protein -
LP093_RS07015 (LP093_06945) 1429781..1430002 - 222 WP_264676284.1 DUF3310 domain-containing protein -
LP093_RS07020 (LP093_06950) 1429999..1430154 - 156 WP_264676283.1 hypothetical protein -
LP093_RS07025 (LP093_06955) 1430291..1430776 - 486 WP_078273444.1 recombination protein NinB -
LP093_RS07030 (LP093_06960) 1430840..1431517 - 678 WP_264720604.1 BRO family protein -
LP093_RS07035 (LP093_06965) 1432179..1432376 + 198 WP_264682993.1 ribbon-helix-helix domain-containing protein -
LP093_RS07040 (LP093_06970) 1432423..1432701 - 279 WP_264689775.1 hypothetical protein -
LP093_RS07045 (LP093_06975) 1432698..1433093 - 396 WP_264676281.1 VRR-NUC domain-containing protein -
LP093_RS07050 (LP093_06980) 1433090..1433698 - 609 WP_264676191.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1372907..1471301 98394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226402 WP_264676287.1 NZ_CP087859:1428728-1428910 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226402 NZ_CP122457:4164500-4164916 [Salmonella enterica subsp. enterica]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTTGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCGGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226402 WP_264676286.1 NZ_CP087859:1428972-1429385 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226402 NZ_CP122457:4164273-4164503 [Salmonella enterica subsp. enterica]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References