Detailed information of TA system TA226401

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 668857..669400
• Replicon: chromosome
• Accession: NZ_CP087859
• Organism: Moraxella bovis strain SAM57983

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LP093_RS03440
• Protein ID: WP_245952240.1
• Coordinates: 669173..669400 (-)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LP093_RS03435
• Protein ID: WP_078273964.1
• Coordinates: 668857..669192 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP093_RS03415 (LP093_03385)	664017..665099	-	1083	WP_078273961.1	tRNA pseudouridine(13) synthase TruD	-
LP093_RS03420 (LP093_03390)	665233..666000	-	768	WP_112742541.1	carbonic anhydrase family protein	-
LP093_RS03425 (LP093_03395)	666646..667827	-	1182	WP_078274027.1	fatty acid desaturase	-
LP093_RS03430 (LP093_03400)	668089..668673	+	585	Protein_660	TetR/AcrR family transcriptional regulator	-
LP093_RS03435 (LP093_03405)	668857..669192	-	336	WP_078273964.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LP093_RS03440 (LP093_03410)	669173..669400	-	228	WP_245952240.1	hypothetical protein	Toxin
LP093_RS03445 (LP093_03415)	669632..670339	+	708	WP_264675942.1	ParA family protein	-
LP093_RS03450 (LP093_03420)	670429..671814	-	1386	WP_078273966.1	APC family permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8451.18 Da
• Isoelectric Point: 4.5519

>T226401 WP_245952240.1 NZ_CP087859:c669400-669173 [Moraxella bovis]
ISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQTHEHNDN

Nucleotide

• Length: 228 bp

>T226401 NZ_CP122457:4078053-4078178 [Salmonella enterica subsp. enterica]
ATGGAAGCCGAAAAAGACCCCGGCTACTGGCAGGAAGTCTACCGTCCGACCTATCTCGGGCAACAGATTTATCTGAAATT
TATTGTTAAAGATGATGTGGTTATCGTCTCATTTAAGGAGAAATAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12189.67 Da
• Isoelectric Point: 4.5658

>AT226401 WP_078273964.1 NZ_CP087859:c669192-668857 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Nucleotide

• Length: 336 bp

>AT226401 NZ_CP122457:4078181-4078582 [Salmonella enterica subsp. enterica]
ATGAAATGTCCTACTTGTGGCGGTGCAGATCTGAAACATGAAACCCGCGATGTTGAATACGAGTACAAAGGTTTCAAAAC
AATCATTCGCGGCATTACTGGCGACTATTGTGGCACATGTGGTGAAGCCGTTCTGGGTGATGAAGCGGGCGACAAATACA
TGGCGGCAATCACCGCCTTTAACCGCCTGGTGAATGCCGAAGAAGTGGATCCGGCATTCATCGCCTCTGTACGTAAGCGC
CTGAAACTGGACCAACGCCAGGCAGCGGAGATTTTTGGCGGAGGTGTTAATGCCTTCAGCCGTTATGAAACAGGCCGCGT
TGCACCACCACGTTCTTTGGTCCTGTTATTTAAGGCGTTAGAGAAGCATCCGGAGATACTGGAAGAGATCAAATACGCCT
GA