Detailed information of TA system TA226400

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 429619..430271
• Replicon: chromosome
• Accession: NZ_CP087859
• Organism: Moraxella bovis strain SAM57983

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP093_RS02175
• Protein ID: WP_078275188.1
• Coordinates: 429879..430271 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP093_RS02170
• Protein ID: WP_264675982.1
• Coordinates: 429619..429882 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP093_RS02140 (LP093_02130)	424904..426238	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP093_RS02145 (LP093_02135)	426382..426675	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP093_RS02150 (LP093_02140)	426668..426940	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP093_RS02155 (LP093_02145)	427005..427460	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP093_RS02160 (LP093_02150)	427545..427922	+	378	WP_264675984.1	hypothetical protein	-
LP093_RS02165 (LP093_02155)	428280..429539	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP093_RS02170 (LP093_02160)	429619..429882	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LP093_RS02175 (LP093_02165)	429879..430271	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP093_RS02180 (LP093_02170)	430394..430924	+	531	WP_078275187.1	HI_0552 family protein	-
LP093_RS02185 (LP093_02175)	430921..431487	-	567	WP_078275186.1	hypothetical protein	-
LP093_RS02190 (LP093_02180)	431490..431726	-	237	WP_078275185.1	sulfurtransferase TusA	-
LP093_RS02195 (LP093_02185)	431723..432181	-	459	WP_078275184.1	acyl-CoA thioesterase	-
LP093_RS02200 (LP093_02190)	432261..433283	-	1023	WP_078275183.1	hypothetical protein	-
LP093_RS02205 (LP093_02195)	433314..434192	-	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP093_RS02210 (LP093_02200)	434238..435179	-	942	WP_078275181.1	hydroxymethylbilane synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226400 WP_078275188.1 NZ_CP087859:429879-430271 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226400 NZ_CP122457:3611292-3611549 [Salmonella enterica subsp. enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTATATAACCACCTGTTACTCACAAATCCCCAGCCT
GCACCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10153.49 Da
• Isoelectric Point: 6.3724

>AT226400 WP_264675982.1 NZ_CP087859:429619-429882 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226400 NZ_CP122457:c3611467-3611145 [Salmonella enterica subsp. enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAACAGGTGGTTATATAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACTGTGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCCGGGGCCGTAT
TTT