Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1718282..1718907 Replicon chromosome
Accession NC_010337
Organism Heliobacterium modesticaldum Ice1

Toxin (Protein)


Gene name mazF Uniprot ID B0TE84
Locus tag HM1_RS07695 Protein ID WP_012282784.1
Coordinates 1718557..1718907 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B0TE83
Locus tag HM1_RS07690 Protein ID WP_012282783.1
Coordinates 1718282..1718551 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HM1_RS07660 1713452..1713868 + 417 WP_207643767.1 ATP-binding protein -
HM1_RS07665 1713925..1714407 + 483 WP_012282778.1 chemotaxis protein CheW -
HM1_RS07670 1714470..1714901 + 432 WP_202943735.1 holo-ACP synthase -
HM1_RS07675 1714889..1716436 + 1548 WP_012282780.1 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase -
HM1_RS07680 1716473..1716943 + 471 WP_041313566.1 CBS domain-containing protein -
HM1_RS07685 1716955..1718184 + 1230 WP_012282782.1 alanine racemase -
HM1_RS07690 1718282..1718551 + 270 WP_012282783.1 ribbon-helix-helix protein, CopG family Antitoxin
HM1_RS07695 1718557..1718907 + 351 WP_012282784.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HM1_RS07700 1718982..1719719 + 738 WP_012282785.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
HM1_RS14620 1719719..1720879 + 1161 WP_012282786.1 HD-GYP domain-containing protein -
HM1_RS07710 1720912..1721913 + 1002 WP_012282787.1 asparaginase -
HM1_RS07715 1721918..1723174 + 1257 WP_012282788.1 amidohydrolase family protein -
HM1_RS07720 1723427..1723861 + 435 WP_012282789.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12829.83 Da        Isoelectric Point: 5.8816

>T22640 WP_012282784.1 NC_010337:1718557-1718907 [Heliobacterium modesticaldum Ice1]
MAIRRGEVYYAELNPVVGSEQGGTRPVLIIQNDIGNQYSPTTIVAAITSQISKAKLPTHVEVPARRSGLDRDSVVLLEQI
RTIDKTRLREKIGMLDDEMMDKVARALEISLGLVDI

Download         Length: 351 bp

>T22640 NC_010337:1718557-1718907 [Heliobacterium modesticaldum Ice1]
ATGGCCATACGCAGAGGAGAAGTTTACTACGCCGAACTGAACCCGGTCGTCGGCTCGGAACAGGGAGGAACCCGCCCCGT
TCTGATCATTCAGAACGACATCGGCAACCAATACTCTCCCACCACCATCGTCGCCGCCATCACCTCCCAGATCAGCAAGG
CCAAACTGCCGACCCATGTGGAAGTGCCAGCCCGCCGCAGCGGGCTGGACCGGGATTCGGTCGTCTTGCTGGAGCAGATC
CGCACTATCGATAAGACCCGCCTTCGTGAAAAAATCGGCATGCTCGATGACGAAATGATGGATAAGGTCGCTCGGGCGCT
GGAGATCAGTCTGGGGCTTGTCGATATCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10527.29 Da        Isoelectric Point: 7.0175

>AT22640 WP_012282783.1 NC_010337:1718282-1718551 [Heliobacterium modesticaldum Ice1]
VPELKRIQVTLPESLLDELDRVLMAEKMNRSQLIREAVNLYMSEHKRKVLRDQMRRGYAEMARINLELALEGFVAEVDVE
RLYEARLAR

Download         Length: 270 bp

>AT22640 NC_010337:1718282-1718551 [Heliobacterium modesticaldum Ice1]
GTGCCCGAGTTGAAACGCATTCAGGTTACCTTGCCGGAATCATTGTTGGACGAACTGGATCGGGTATTGATGGCCGAGAA
GATGAACCGCAGCCAACTCATTCGGGAAGCGGTGAACTTATACATGAGCGAGCACAAGCGCAAGGTCTTGCGCGATCAGA
TGCGCCGGGGCTATGCCGAAATGGCCCGCATCAACCTGGAACTTGCGCTGGAAGGCTTTGTCGCCGAGGTAGATGTGGAG
CGCCTGTACGAGGCGAGGTTGGCCAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A845L5F8

Antitoxin

Source ID Structure
AlphaFold DB B0TE83

References