Detailed information of TA system TA226399

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 426382..426940
• Replicon: chromosome
• Accession: NZ_CP087859
• Organism: Moraxella bovis strain SAM57983

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP093_RS02150
• Protein ID: WP_228157760.1
• Coordinates: 426668..426940 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP093_RS02145
• Protein ID: WP_029103533.1
• Coordinates: 426382..426675 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP093_RS02125 (LP093_02115)	421893..423227	-	1335	WP_078275195.1	valine--pyruvate transaminase	-
LP093_RS02130 (LP093_02120)	423347..423958	+	612	WP_112741794.1	methyltransferase	-
LP093_RS02135 (LP093_02125)	423979..424695	+	717	WP_078275193.1	hypothetical protein	-
LP093_RS02140 (LP093_02130)	424904..426238	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP093_RS02145 (LP093_02135)	426382..426675	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP093_RS02150 (LP093_02140)	426668..426940	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP093_RS02155 (LP093_02145)	427005..427460	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP093_RS02160 (LP093_02150)	427545..427922	+	378	WP_264675984.1	hypothetical protein	-
LP093_RS02165 (LP093_02155)	428280..429539	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP093_RS02170 (LP093_02160)	429619..429882	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP093_RS02175 (LP093_02165)	429879..430271	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP093_RS02180 (LP093_02170)	430394..430924	+	531	WP_078275187.1	HI_0552 family protein	-
LP093_RS02185 (LP093_02175)	430921..431487	-	567	WP_078275186.1	hypothetical protein	-
LP093_RS02190 (LP093_02180)	431490..431726	-	237	WP_078275185.1	sulfurtransferase TusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226399 WP_228157760.1 NZ_CP087859:426668-426940 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226399 NZ_CP122457:3412784-3413002 [Salmonella enterica subsp. enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226399 WP_029103533.1 NZ_CP087859:426382-426675 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226399 NZ_CP122457:3412382-3412756 [Salmonella enterica subsp. enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6