Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2291920..2292572 Replicon chromosome
Accession NZ_CP087856
Organism Moraxella bovis strain SAM57987

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP115_RS11735 Protein ID WP_078275188.1
Coordinates 2291920..2292312 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP115_RS11740 Protein ID WP_264675982.1
Coordinates 2292309..2292572 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP115_RS11700 (LP115_11595) 2287012..2287953 + 942 WP_078275181.1 hydroxymethylbilane synthase -
LP115_RS11705 (LP115_11600) 2287999..2288877 + 879 WP_112741796.1 uroporphyrinogen-III synthase -
LP115_RS11710 (LP115_11605) 2288908..2289930 + 1023 WP_078275183.1 hypothetical protein -
LP115_RS11715 (LP115_11610) 2290010..2290468 + 459 WP_078275184.1 acyl-CoA thioesterase -
LP115_RS11720 (LP115_11615) 2290465..2290701 + 237 WP_078275185.1 sulfurtransferase TusA -
LP115_RS11725 (LP115_11620) 2290704..2291270 + 567 WP_078275186.1 hypothetical protein -
LP115_RS11730 (LP115_11625) 2291267..2291797 - 531 WP_078275187.1 HI_0552 family protein -
LP115_RS11735 (LP115_11630) 2291920..2292312 - 393 WP_078275188.1 type II toxin-antitoxin system VapC family toxin Toxin
LP115_RS11740 (LP115_11635) 2292309..2292572 - 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP115_RS11745 (LP115_11640) 2292652..2293911 - 1260 WP_264675983.1 replication-associated recombination protein A -
LP115_RS11750 (LP115_11645) 2294269..2294646 - 378 WP_264675984.1 hypothetical protein -
LP115_RS11755 (LP115_11650) 2294731..2295186 + 456 WP_264675985.1 type IV secretion protein Rhs -
LP115_RS11760 (LP115_11655) 2295251..2295523 - 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP115_RS11765 (LP115_11660) 2295516..2295809 - 294 WP_029103533.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP115_RS11770 (LP115_11665) 2295953..2297287 - 1335 WP_112741795.1 deoxyguanosinetriphosphate triphosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14689.79 Da        Isoelectric Point: 4.7370

>T226395 WP_078275188.1 NZ_CP087856:c2292312-2291920 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226395 NZ_CP122457:845942-846340 [Salmonella enterica subsp. enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCATAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTTGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226395 WP_264675982.1 NZ_CP087856:c2292572-2292309 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226395 NZ_CP122457:845715-845942 [Salmonella enterica subsp. enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References