Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2052863..2053439 Replicon chromosome
Accession NZ_CP087856
Organism Moraxella bovis strain SAM57987

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP115_RS10480 Protein ID WP_264676341.1
Coordinates 2052863..2053123 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP115_RS10485 Protein ID WP_078273964.1
Coordinates 2053104..2053439 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP115_RS10465 (LP115_10385) 2047894..2049969 + 2076 WP_264675941.1 NAD-dependent DNA ligase LigA -
LP115_RS10470 (LP115_10390) 2050482..2051867 + 1386 WP_078273966.1 APC family permease -
LP115_RS10475 (LP115_10395) 2051957..2052664 - 708 WP_264675942.1 ParA family protein -
LP115_RS10480 (LP115_10400) 2052863..2053123 + 261 WP_264676341.1 type II toxin-antitoxin system HicA family toxin Toxin
LP115_RS10485 (LP115_10405) 2053104..2053439 + 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP115_RS10490 (LP115_10410) 2053623..2054207 - 585 Protein_2053 TetR/AcrR family transcriptional regulator -
LP115_RS10495 (LP115_10415) 2054469..2055650 + 1182 WP_078274027.1 fatty acid desaturase -
LP115_RS10500 (LP115_10420) 2056296..2057063 + 768 WP_112742541.1 carbonic anhydrase family protein -
LP115_RS10505 (LP115_10425) 2057197..2058279 + 1083 WP_078273961.1 tRNA pseudouridine(13) synthase TruD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9551.46 Da        Isoelectric Point: 4.3376

>T226394 WP_264676341.1 NZ_CP087856:2052863-2053123 [Moraxella bovis]
IEALFVALGADISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQT
HEHNDN

Download         Length: 261 bp

>T226394 NZ_CP122457:836193-836606 [Salmonella enterica subsp. enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226394 WP_078273964.1 NZ_CP087856:2053104-2053439 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226394 NZ_CP122457:835946-836212 [Salmonella enterica subsp. enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References