Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1310912..1311569 Replicon chromosome
Accession NZ_CP087856
Organism Moraxella bovis strain SAM57987

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP115_RS07025 Protein ID WP_264676287.1
Coordinates 1311387..1311569 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP115_RS07020 Protein ID WP_264676286.1
Coordinates 1310912..1311325 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP115_RS06965 (LP115_06910) 1306096..1306371 + 276 WP_112742261.1 YdaS family helix-turn-helix protein -
LP115_RS06970 (LP115_06915) 1306439..1307122 + 684 WP_264676189.1 Rha family transcriptional regulator -
LP115_RS06975 (LP115_06920) 1307119..1307928 + 810 WP_264676696.1 replication protein -
LP115_RS06980 (LP115_06925) 1307925..1308533 + 609 WP_078273440.1 hypothetical protein -
LP115_RS06985 (LP115_06930) 1308530..1308937 + 408 WP_112742083.1 VRR-NUC domain-containing protein -
LP115_RS06990 (LP115_06935) 1308934..1309212 + 279 WP_078273442.1 DUF968 domain-containing protein -
LP115_RS06995 (LP115_06940) 1309234..1309524 + 291 WP_112742084.1 hypothetical protein -
LP115_RS07000 (LP115_06945) 1309521..1310006 + 486 WP_078273444.1 recombination protein NinB -
LP115_RS07005 (LP115_06950) 1310143..1310298 + 156 WP_264676283.1 hypothetical protein -
LP115_RS07010 (LP115_06955) 1310295..1310516 + 222 WP_264676284.1 DUF3310 domain-containing protein -
LP115_RS07015 (LP115_06960) 1310500..1310901 + 402 WP_264676285.1 antiterminator Q family protein -
LP115_RS07020 (LP115_06965) 1310912..1311325 - 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP115_RS07025 (LP115_06970) 1311387..1311569 - 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP115_RS07030 (LP115_06975) 1311969..1312673 + 705 WP_264676288.1 BRO family protein -
LP115_RS07035 (LP115_06980) 1313100..1313300 - 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP115_RS07040 (LP115_06985) 1313337..1313546 - 210 WP_264676290.1 hypothetical protein -
LP115_RS07045 (LP115_06990) 1313660..1314199 + 540 WP_264676291.1 terminase small subunit -
LP115_RS07050 (LP115_06995) 1314199..1315596 + 1398 WP_264676292.1 phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1292528..1346534 54006


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226393 WP_264676287.1 NZ_CP087856:c1311569-1311387 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226393 NZ_CP122457:316683-317051 [Salmonella enterica subsp. enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226393 WP_264676286.1 NZ_CP087856:c1311325-1310912 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226393 NZ_CP122457:316465-316686 [Salmonella enterica subsp. enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References